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Journal of Virology, January 1999, p. 362-367, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants

Katherine Luzuriaga,1,* Hulin Wu,2 Margaret McManus,1 Paula Britto,2 William Borkowsky,3 Sandra Burchett,4 Betsy Smith,5 Lynne Mofenson,6 John L. Sullivan,1 and the PACTG 356 Investigatorsdagger

Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester,1 and Statistical and Data Analysis Center, Harvard School of Public Health,2 and Boston Children's Hospital,4 Boston, Massachusetts; Department of Pediatrics, New York University, New York, New York3; and Division of AIDS, National Institute of Allergy and Infectious Diseases,5 and Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health & Human Development,6 National Institutes of Health, Bethesda, Maryland

Received 24 June 1998/Accepted 8 October 1998

Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

* Corresponding author. Mailing address: Department of Pediatrics, Program in Molecular Medicine, Room 318, Biotech 2, 373 Plantation St., Worcester, MA 01605. Phone: (508) 856-6282. Fax: (508) 856-5500. E-mail: katherine.luzuriaga{at}ummed.edu.

dagger PACTG 356 Investigators who contributed to this study include George Johnson (Medical University of South Carolina, Charleston), Hannah Gay (University of Mississippi Medical Center, Jackson), Stuart Starr (Children's Hospital, Philadelphia, Philadelphia, Pa.), Diane Wara (University of California, San Francisco, San Francisco), Yvonne Bryson (University of California, Los Angeles, Los Angeles), Colleen Cunningham (SUNY Syracuse, Syracuse, N.Y.), Ross McKinney, Jr. (Duke University Medical Center, Durham, N.C.), and Barbara Stechenberg (Baystate Medical Center, Springfield, Mass.).

Journal of Virology, January 1999, p. 362-367, Vol. 73, No. 1
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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