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Journal of Virology, September 1998, p. 7703-7706, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection

Gunasegaran Karupiah,1,* Jian-He Chen,1 Carl F. Nathan,2 Surendran Mahalingam,1 and John D. MacMicking2,dagger

Host Defense Laboratory, Viral Engineering and Cytokines Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia,1 and Beatrice and Samuel A. Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, New York 100212

Received 28 May 1998/Accepted 17 June 1998

To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e., gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

* Corresponding author. Mailing address: Division of Immunology and Cell Biology, The John Curtin School of Medical Research, The Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia. Phone: 61 2 6249 2627. Fax: 61 2 6249 2595. E-mail: Guna.Karupiah{at}anu.edu.au.

dagger Present address: Laboratory of Immunology, HHMI, The Rockefeller University, New York, NY 10021.

Journal of Virology, September 1998, p. 7703-7706, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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