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Journal of Virology, September 1998, p. 7664-7668, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Human T-Lymphotropic Virus Type 2 (HTLV-2) Provirus in Circulating Cells of the Monocyte/Macrophage Lineage in Patients Dually Infected with Human Immunodeficiency Virus Type 1 and HTLV-2 and Having Predominantly Sensory Polyneuropathy

Gianguglielmo Zehender,1,* Luca Meroni,1 Stefania Varchetta,1 Chiara De Maddalena,1 Barbara Cavalli,1 Monica Gianotto,1 Anna Bianchi Bosisio,1 Chiara Colasante,1 Giuliano Rizzardini,2 Mauro Moroni,1 and Massimo Galli1

Istituto di Malattie Infettive e Tropicali, Università degli Studi di Milano,1 and I Divisione di Malattie Infettive, Ospedale "L. Sacco,"2 Milan, Italy

Received 5 January 1998/Accepted 22 May 1998

We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Tropicali, Università degli Studi di Milano, c/o Ospedale L. Sacco, Via G.B. Grassi, 74, 20157 Milan, Italy. Phone: 39-2-38200319. Fax: 39-2-3566644. E-mail: zehender{at}imiucca.csi.unimi.it.

Journal of Virology, September 1998, p. 7664-7668, Vol. 72, No. 9
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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