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J Virol, July 1998, p. 6215-6217, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

CXCR4 and CCR5 Genetic Polymorphisms in Long-Term Nonprogressive Human Immunodeficiency Virus Infection: Lack of Association with Mutations other than CCR5-Delta 32

Oren J. Cohen,* Stefania Paolucci,dagger Steven M. Bende,Dagger MaryBeth Daucher, Hiroyuki Moriuchi, Masako Moriuchi, Claudia Cicala, Richard T. Davey Jr., Barbara Baird, and Anthony S. Fauci

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Received 12 June 1997/Accepted 13 April 1998

Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Delta 32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta 32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.

* Corresponding author. Mailing address: National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, 10 Center Dr., MSC 1876, Bldg. 10, Rm. 11B13, Bethesda, MD 20892-1876. Phone: (301) 496-5508. Fax: (301) 402-0070. E-mail: OCohen{at}nih.gov.

dagger Present address: Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

Dagger Present address: Division of AIDS, NIAID, Bethesda, MD 20892-7620.

J Virol, July 1998, p. 6215-6217, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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