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J Virol, July 1998, p. 6195-6198, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Site-Specific Integration of Adeno-Associated Virus into an Episome with the Target Locus via a Deletion-Substitution Mechanism

Julie Dyall1 and Kenneth I. Berns2,*

Department of Microbiology, W. R. Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021,1 and University of Florida College of Medicine, Gainesville, Florida 326102

Received 3 February 1998/Accepted 2 April 1998

Five site-specific adeno-associated virus integrants generated in a model system with an Epstein-Barr virus- based shuttle vector have been characterized. The results suggest a deletion-substitution mechanism of recombination.

* Corresponding author. Mailing address: Dean's Office, University of Florida College of Medicine, Box 100215 JHMHC, Gainesville, Florida 32610. Phone: (352) 392-5397. Fax: (352) 392-6482.

J Virol, July 1998, p. 6195-6198, Vol. 72, No. 7
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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