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J Virol, June 1998, p. 5182-5188, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Limited Transmission of Kaposi's Sarcoma-Associated Herpesvirus in Cultured Cells

Rolf Renne,1 David Blackbourn,2 Denise Whitby,3 Jay Levy,2 and Don Ganem1,2,*

Howard Hughes Medical Institute and Department of Microbiology and Immunology1 and Department of Medicine,2 University of California, San Francisco, San Francisco, California 94143-0414, and Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB, United Kingdom3

Received 29 December 1997/Accepted 10 March 1998

Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of Kaposi's sarcoma. Although virions can be produced in high yield from latently infected B-cell lines treated with phorbol esters, little is known about the infectivity of such virus, and efficient serial propagation of KSHV has been problematic. Here we report on the infectivity of KSHV produced from phorbol-induced BCBL-1 cells, employing an assay based on the detection of a spliced late mRNA by a sensitive reverse transcriptase PCR (RT-PCR) method. The results of this study confirm previous observations that 293 cells are susceptible to viral infection; however, infection with BCBL-1-derived virus is inefficient and the pattern of viral gene expression in infected cells may not fully reproduce that of authentic lytic infection. In keeping with this finding, serial propagation of BCBL-1-derived virus could not be demonstrated on 293 cells. Eleven of 38 other cell lines tested also supported KSHV infection, as judged by this RT-PCR assay, including cells of B-cell, endothelial, epithelial, and fibroblastic origin; however, in all cases, infection proceeded at or below the levels observed in 293 cells.

* Corresponding author. Mailing address: Department of Microbiology, UCSF, 513 Parnassus Ave., San Francisco, CA 94143-0414. Phone: (415) 476-2826. Fax: (415) 476-0939. E-mail: ganem{at}socrates.ucsf.edu.

J Virol, June 1998, p. 5182-5188, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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