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J Virol, June 1998, p. 4704-4711, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Vaccination with a Recombinant Vesicular Stomatitis Virus Expressing an Influenza Virus Hemagglutinin Provides Complete Protection from Influenza Virus Challenge

Anjeanette Roberts,1 Evelyne Kretzschmar,1,dagger Archibald S. Perkins,1 John Forman,1 Ryan Price,1 Linda Buonocore,1 Yoshihiro Kawaoka,2,Dagger and John K. Rose1,*

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and St. Jude Children's Research Hospital, Memphis, Tennessee 381012

Received 11 November 1997/Accepted 2 March 1998

Since the development of a system for generating vesicular stomatitis virus (VSV) from plasmid DNAs, our laboratory has reported the expression of several different glycoproteins from recombinant VSVs. In one of these studies, high-level expression of an influenza virus hemagglutinin (HA) from a recombinant VSV-HA and efficient incorporation of the HA protein into the virions was reported (E. Kretzschmar, L. Buonocore, M. J. Schnell, and J. K. Rose, J. Virol. 71:5982-5989, 1997). We report here that VSV-HA is an effective intranasal vaccine vector that raises high levels of neutralizing antibody to influenza virus and completely protects mice from bronchial pneumonia caused by challenge with a lethal dose of influenza A virus. Additionally, these recombinant VSVs are less pathogenic than wild-type VSV (serotype Indiana). This vector-associated pathogenicity was subsequently eliminated through introduction of specific attenuating deletions. These live attenuated recombinant VSVs have great potential as vaccine vectors.

* Corresponding author. Mailing address: Department of Pathology, BML 342, Yale University School of Medicine, 310 Cedar St., New Haven, CT 06510. Phone: (203) 785-6794. Fax: (203) 785-7467. E-mail: jrose{at}biomed.med.yale.edu.

dagger Present address: Gesellschaft f. Transfusionmedizin Duisburg mbH, 47051 Duisburg, Germany.

Dagger Present address: Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706.

J Virol, June 1998, p. 4704-4711, Vol. 72, No. 6
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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