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J Virol, May 1998, p. 4430-4433, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Herpes Simplex Virus 2 UL45 Is a Type II Membrane Protein

Adam S. Cockrell and Martin I. Muggeridge*

Department of Microbiology and Immunology, Louisiana State University School of Medicine, Shreveport, Louisiana 71130

Received 24 October 1997/Accepted 2 February 1998

In addition to eleven glycoproteins, the herpes simplex virus type 2 (HSV-2) genome encodes several proteins with potential membrane-spanning segments but no asparagine-linked carbohydrates. One of these is UL45. Fractionation of infected cells showed that HSV-2 UL45 is an integral membrane protein, and analysis of UL45 mutants with potential glycosylation sites showed that it has a type II membrane orientation, the first HSV protein known to have this orientation. Furthermore, it is detectable in infected cells at a time similar to that when glycoproteins gB and gD are detected, consistent with a role in cell-cell fusion, which has previously been found for HSV-1 UL45.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Louisiana State University School of Medicine, 1501 Kings Highway, Shreveport, LA 71130. Phone: (318) 675-7571. Fax: (318) 675-5764. E-mail: mmugge{at}lsumc.edu.

J Virol, May 1998, p. 4430-4433, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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