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J Virol, May 1998, p. 4427-4429, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Functions of Conserved Motifs in the RNA-Dependent RNA Polymerase of a Yeast Double-Stranded RNA Virus

Eric Routhier and Jeremy A. Bruenn*

Department of Biological Sciences, SUNY---Buffalo, Buffalo, New York 14260

Received 14 October 1997/Accepted 29 January 1998

At least eight conserved motifs are visible in the totivirus RNA-dependent RNA polymerase (RDRP). We have systematically altered each of these in the Saccharomyces cerevisiae double-stranded RNA virus ScVL1 by substituting the conserved motifs from a giardiavirus. The results help define the conserved regions of the RDRP involved in polymerase function and those essential for other reasons.

* Corresponding author. Mailing address: Department of Biological Sciences, SUNY---Buffalo, Cooke Hall, Box 611300, Buffalo, NY 14260-1300. Phone: (716) 645-2868. Fax: (716) 645-3776. E-mail: cambruen{at}acsu.buffalo.edu.

J Virol, May 1998, p. 4427-4429, Vol. 72, No. 5
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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