This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ball-Goodrich, L. J.
Right arrow Articles by Jacoby, R. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ball-Goodrich, L. J.
Right arrow Articles by Jacoby, R. O.

 Previous Article  |  Next Article 

J Virol, April 1998, p. 3289-3299, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rat Parvovirus Type 1: the Prototype for a New Rodent Parvovirus Serogroup

Lisa J. Ball-Goodrich,* Stuart E. Leland,dagger Elizabeth A. Johnson, Frank X. Paturzo, and Robert O. Jacoby

Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8016

Received 15 September 1997/Accepted 12 December 1997

A newly recognized parvovirus of laboratory rats, designated rat parvovirus type 1a (RPV-1a), was found to be antigenically distinct. It was cloned, sequenced, and compared with the University of Massachusetts strain of rat virus (RV-UMass) and other autonomous parvoviruses. RPV-1a VP1 identity with these viruses never exceeded 69%, thus explaining its antigenic divergence. In addition, RPV-1a had reduced amino acid identity in NS coding regions (82%), reflecting phylogenetic divergence from other rodent parvoviruses. RPV-1a infection in rats had a predilection for endothelium and lymphoid tissues as previously reported for RV. Infectious RPV-1a was isolated 3 weeks after inoculation of infant rats, suggesting that it, like RV, may result in persistent infection. In contrast to RV, RPV-1a was enterotropic, a characteristic previously associated with parvovirus infections of mice rather than rats. RPV-1a also differed from RV in that infection was nonpathogenic for infant rats under conditions where RV infection causes high morbidity and mortality. Thus, RPV-1a is the prototype virus of an antigenically, genetically, and biologically distinct rodent parvovirus serogroup.

* Corresponding author. Mailing address: Section of Comparative Medicine, Yale University School of Medicine P.O. Box 208016, New Haven, CT 06520-8016. Phone: (203) 785-2520. Fax: (203) 785-7499. E-mail: lisa.ball-goodrich{at}yale.edu.

dagger Present address: University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA 19104-6021.




This article has been cited by other articles:

  • Besselsen, D. G., Romero, M. J., Wagner, A. M., Henderson, K. S., Livingston, R. S. (2006). Identification of novel murine parvovirus strains by epidemiological analysis of naturally infected mice. J. Gen. Virol. 87: 1543-1556 [Abstract] [Full Text]  
  • Wan, C.-H., Soderlund-Venermo, M., Pintel, D. J., Riley, L. K. (2002). Molecular characterization of three newly recognized rat parvoviruses. J. Gen. Virol. 83: 2075-2083 [Abstract] [Full Text]  
  • Ueno, Y., Harada, T., Iseki, H., Ohshima, T., Sugiyama, F., Yagami, K.-i. (2001). Propagation of Rat Parvovirus in Thymic Lymphoma Cell Line C58(NT)D and Subsequent Appearance of a Resistant Cell Clone after Lytic Infection. J. Virol. 75: 3965-3970 [Abstract] [Full Text]  
  • Söderlund-Venermo, M., Riley, L. K., Pintel, D. J. (2001). Construction and initial characterization of an infectious plasmid clone of a newly identified hamster parvovirus. J. Gen. Virol. 82: 919-927 [Abstract] [Full Text]  
  • Lukashov, V. V., Goudsmit, J. (2001). Evolutionary Relationships among Parvoviruses: Virus-Host Coevolution among Autonomous Primate Parvoviruses and Links between Adeno-Associated and Avian Parvoviruses. J. Virol. 75: 2729-2740 [Abstract] [Full Text]  
  • Ball-Goodrich, L. J., Johnson, E., Jacoby, R. (2001). Divergent replication kinetics of two phenotypically different parvoviruses of rats. J. Gen. Virol. 82: 537-546 [Abstract] [Full Text]  
  • Jacoby, R. O., Johnson, E. A., Paturzo, F. X., Ball-Goodrich, L. (2000). Persistent Rat Virus Infection in Smooth Muscle of Euthymic and Athymic Rats. J. Virol. 74: 11841-11848 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»