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J Virol, April 1998, p. 3161-3168, Vol. 72, No. 4
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

Yael D. Korin1 and Jerome A. Zack2,3,*

Department of Pathology and Laboratory Medicine,1 Division of Hematology-Oncology, Department of Medicine,3 and Department of Microbiology and Molecular Genetics,2 University of California, Los Angeles, School of Medicine, Los Angeles, California 90095

Received 24 October 1997/Accepted 22 December 1997

Successful infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile, reverse transcripts. In the present study, we isolated highly purified quiescent T cells and utilized the CD3/CD28 activation pathways as well as cell cycle inhibitors to further define the role of costimulation and cell cycle progression in HIV-1 reverse transcription. Activation with alpha CD3 alone resulted in cell cycle progression into only G1a and incomplete HIV-1 reverse transcription. Costimulation through the CD28 receptor and transition into G1b was required to efficiently complete the reverse transcription process. These findings have relevance to immune activation in vivo, since lymphocytes rendered anergic by a single activation signal would be nonpermissive for productive infection with HIV-1. Importantly, these data also suggest that HIV vector-based genetic transduction strategies might be successful only in target cells that transition into the G1b phase of the cell cycle.

* Corresponding author. Mailing address: Department of Medicine, Division of Hematology-Oncology, and Department of Microbiology and Molecular Genetics, 11-934 Factor Bldg., 10833 Le Conte Ave., Los Angeles, CA 90095. Phone: (310) 794-7765. Fax: (310) 825-6192. E-mail: JZACK{at}UCLA.edu.




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