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J Virol, March 1998, p. 2538-2540, Vol. 72, No. 3
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Nitric Oxide on Poliovirus Infection of Two Human Cell Lines

José A. López-Guerrero* and Luis Carrasco

Centro de Biología Molecular, CSIC-UAM, Universidad Autónoma de Madrid, 28049 Madrid, Spain

Received 29 September 1997/Accepted 8 December 1997

The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, pretreatment with the nitric oxide donor glycerine trinitrate lengthened the course of poliovirus infection.

* Corresponding author. Mailing address: Centro de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain. Phone: 34-1-397-5074. Fax: 34-1-397-4799. E-mail: JALOPEZ{at}TRASTO.CBM.UAM.ES.




This article has been cited by other articles:

  • Rimmelzwaan, G. F., Baars, M. M. J. W., de Lijster, P., Fouchier, R. A. M., Osterhaus, A. D. M. E. (1999). Inhibition of Influenza Virus Replication by Nitric Oxide. J. Virol. 73: 8880-8883 [Abstract] [Full Text]  
  • Reiss, C. S., Komatsu, T. (1998). Does Nitric Oxide Play a Critical Role in Viral Infections?. J. Virol. 72: 4547-4551 [Full Text]  


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