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J Virol, February 1998, p. 1652-1656, Vol. 72, No. 2
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses

Cristina Parolin,1,2 Alessandra Borsetti,1 Hyeryun Choe,1 Michael Farzan,1 Peter Kolchinsky,1 Michael Heesen,3 Qing Ma,4 Craig Gerard,5 Giorgio Palú,2 Martin E. Dorf,3 Timothy Springer,4 and Joseph Sodroski1,6,*

Division of Human Retrovirology, Dana-Farber Cancer Institute,1 Center for Blood Research,4 and Department of Pathology,3 Harvard Medical School, Department of Cancer Biology, Harvard School of Public Health,6 and Perlmutter Laboratory, Children's Hospital, Departments of Medicine and Pediatrics, Beth Israel Hospital and Harvard Medical School,5 Boston, Massachusetts 02115, and Institute of Microbiology, University of Padua, Padua 35121, Italy2

Received 28 March 1997/Accepted 21 October 1997

The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

* Corresponding author. Mailing address: JFB 824, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115. Phone: (617) 632-3371. Fax: (617) 632-4338. E-mail: Joseph_Sodroski{at}dfci.harvard.edu.




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