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J Virol, February 1998, p. 1627-1631, Vol. 72, No. 2
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Herpesvirus Saimiri-Transformed Human CD4+ T-Cell Lines: an Efficient Target Cell System for the Analysis of Human Immunodeficiency Virus-Specific Cytotoxic CD8+ T-Lymphocyte Activity

Monika Bauer,1 Maria Lucchiari-Hartz,2,dagger Helmut Fickenscher,3 Klaus Eichmann,2 Jane McKeating,4 and Andreas Meyerhans1,*

Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, 79104 Freiburg,1 Max-Planck-Institut für Immunbiologie, 79108 Freiburg,2 and Institut für Klinische und Molekulare Virologie, Universität Erlangen Nürnberg, 91054 Erlangen,3 Germany, and School of Animal and Microbial Sciences, University of Reading, Reading, United Kingdom4

Received 28 July 1997/Accepted 3 November 1997

Herpesvirus saimiri growth-transformed human CD4+ T lymphocytes were examined for their suitability as a target cell system for investigating human immunodeficiency virus (HIV)-specific HLA class I-restricted cytotoxic T-cell activity. Besides CD4, they express the chemokine receptors CCR5 and CXCR4, the common coreceptors of HIV. They are infectible by a range of HIV strains, including primary isolates, becoming efficient targets for CD8-positive HIV-specific cytotoxic T lymphocytes.

* Corresponding author. Mailing address: Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany. Phone: 49 761 203 6614. Fax: 49 761 203 6639. E-mail: andreas{at}sun1.ukl.uni-freiburg.de.

dagger Present address: Laboratory of Virus Immunology, Instituto Butantan, Sao Paulo, Brazil.






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