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J Virol, February 1998, p. 1219-1223, Vol. 72, No. 2
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Distribution of Mouse Adenovirus Type 1 in Intraperitoneally and Intranasally Infected Adult Outbred Mice

Adriana E. Kajon,1 Corrie C. Brown,2 and Katherine R. Spindler1,*

Department of Genetics, Franklin College of Arts and Sciences,1 and Department of Veterinary Pathology, College of Veterinary Medicine,2 University of Georgia, Athens, Georgia

Received 2 September 1997/Accepted 14 October 1997

In situ nucleic acid hybridization and immunohistochemistry were used to determine the histological localization of mouse adenovirus type 1 (MAV-1) during acute infection of adult mice infected either intraperitoneally or intranasally with 1,000 PFU of wild-type virus. Organ samples were collected from days 1 to 17 postinfection for the intraperitoneally infected mice and from days 1 to 13 for the intranasally infected mice. Endothelial cells of the brain and spinal cord showed extensive evidence of MAV-1 infection. Endothelial cells in lungs, kidneys, and other organs were also positive for MAV-1, indicating a widespread involvement of the systemic circulation. The presence of viral nucleic acid and/or antigen was also demonstrated in lymphoid tissue. The spleens, Peyer's patches, and peripheral lymph nodes showed positive staining at various times postinfection in mice infected by either route. Virus-infected cells in the spleen exhibited a stellate shape and were localized to the red pulp and germinal centers, suggesting that they are cells of the mononuclear phagocytic system.

* Corresponding author. Mailing address: Department of Genetics, University of Georgia, Life Sciences Bldg., Athens, GA 30602-7223. Phone: (706) 542-8395. Fax: (706) 542-3910. E-mail: spindler{at}uga.cc.uga.edu.




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