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Journal of Virology, December 1998, p. 10275-10280, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Vaccine Protection against a Heterologous, Non-Syncytium-Inducing, Primary Human Immunodeficiency Virus

Marjorie Robert-Guroff,1,* Harvinder Kaur,1 L. Jean Patterson,1 Michel Leno,1 Anthony J. Conley,2 Philip M. McKenna,2 Phillip D. Markham,3 Ersell Richardson,1 Kristine Aldrich,1 Kamalpreet Arora,1 Lalita Murty,1 Lucretia Carter,1 Susan Zolla-Pazner,4 and Faruk Sinangil5

Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-42551; Merck Research Laboratories, West Point, Pennsylvania 194862; Advanced BioScience Laboratories, Inc., Kensington, Maryland 20895-10783; VA and NYU Medical Centers, New York, New York 100104; and Chiron Corporation, Emeryville, California 94608-29165

Received 29 June 1998/Accepted 9 September 1998

Vaccine-induced protection of chimpanzees against laboratory-adapted and syncytium-inducing, multiply passaged primary human immunodeficiency virus type 1 (HIV-1) isolates, but not against non-syncytium-inducing, minimally passaged ones, has been demonstrated. Following challenge with such an isolate, HIV-15016, we obtained complete protection in one of three chimpanzees previously protected against low- and high-dose HIV-1SF2 exposures after immunization with an adenovirus-HIV-1MN gp160 priming-HIV-1SF2 gp120 boosting regimen. At challenge, the protected chimpanzee exhibited broad humoral immunity, including neutralizing antibody activity. These results demonstrate the potential of this combination vaccine strategy and suggest that vaccine protection against an HIV isolate relevant to infection of people is feasible.

* Corresponding author. Mailing address: Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Building 37, Room 6B03, Bethesda, MD 20892-4255. Phone: (301) 496-2114. Fax: (301) 496-8394. E-mail: guroffm{at}dc37a.nci.nih.gov.

Journal of Virology, December 1998, p. 10275-10280, Vol. 72, No. 12
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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