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Journal of Virology, October 1998, p. 8403-8407, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Strain-Specific Differences in LFA-1 Induction on Measles Virus-Infected Monocytes and Adhesion and Viral Transmission to Endothelial Cells

Kimberly B. Hummel,1,* William J. Bellini,1 and Margaret K. Offermann2

Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 and The Winship Cancer Center, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 303222

Received 28 August 1997/Accepted 8 July 1998

Measles virus (MV) infection of monocytes induces leukocyte function-associated antigen-1 (LFA-1), an integrin that mediates intercellular adhesion to the endothelium. Thus, an increase in LFA-1 expression could lead to enhanced monocyte adherence and virus dissemination to endothelial cells (ECs) and potentially be an important means of distinction between MV strains. We identified both vaccine and wild-type strains that induced LFA-1 and others that failed to induce. Although adhesion of MV-infected monocytes and viral transmission to ECs was demonstrated, strain-specific differences were not correlated with LFA-1 induction. MV infection of ECs was dramatically reduced in the absence of cell contact, suggesting virus dissemination by cell-cell transmission.

* Corresponding author. Mailing address: 1600 Clifton Rd. Mailstop C-22, Atlanta, GA 30333. Phone: (404) 639-3513. Fax: (404) 639-4187. E-mail: kbh2{at}cdc.gov.

Journal of Virology, October 1998, p. 8403-8407, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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