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Journal of Virology, October 1998, p. 8327-8331, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protection of Mice against Lethal Coxsackievirus B3 Infection by Using DNA Immunization

Andreas Henke,1,* Elke Wagner,1 J. Lindsay Whitton,2 Roland Zell,1 and Axel Stelzner1

Institute of Virology, Medical Center, Friedrich Schiller University, 07745 Jena, Germany,1 and Department of Neuropharmacology, CVN-9, The Scripps Research Institute, La Jolla, California 920372

Received 17 February 1998/Accepted 16 June 1998

Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.

* Corresponding author. Mailing address: Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str. 10, 07745 Jena, Germany. Phone: (49) 3641 657215. Fax: (49) 3641 657202. E-mail: i6hean{at}rz.uni-jena.de.

Journal of Virology, October 1998, p. 8327-8331, Vol. 72, No. 10
0022-538X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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