This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuno, G.
Right arrow Articles by Cropp, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuno, G.
Right arrow Articles by Cropp, C. B.

 Previous Article  |  Next Article 

J. Virol., 01 1998, 73-83, Vol 72, No. 1

Phylogeny of the genus Flavivirus

G Kuno, GJ Chang, KR Tsuchiya, N Karabatsos and CB Cropp
Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522-2087, USA. GOK1@CDC.GOV

We undertook a comprehensive phylogenetic study to establish the genetic relationship among the viruses of the genus Flavivirus and to compare the classification based on molecular phylogeny with the existing serologic method. By using a combination of quantitative definitions (bootstrap support level and the pairwise nucleotide sequence identity), the viruses could be classified into clusters, clades, and species. Our phylogenetic study revealed for the first time that from the putative ancestor two branches, non-vector and vector- borne virus clusters, evolved and from the latter cluster emerged tick- borne and mosquito-borne virus clusters. Provided that the theory of arthropod association being an acquired trait was correct, pairwise nucleotide sequence identity among these three clusters provided supporting data for a possibility that the non-vector cluster evolved first, followed by the separation of tick-borne and mosquito-borne virus clusters in that order. Clades established in our study correlated significantly with existing antigenic complexes. We also resolved many of the past taxonomic problems by establishing phylogenetic relationships of the antigenically unclassified viruses with the well-established viruses and by identifying synonymous viruses.


This article has been cited by other articles:

  • Bondre, V. P., Sapkal, G. N., Yergolkar, P. N., Fulmali, P. V., Sankararaman, V., Ayachit, V. M., Mishra, A. C., Gore, M. M. (2009). Genetic characterization of Bagaza virus (BAGV) isolated in India and evidence of anti-BAGV antibodies in sera collected from encephalitis patients. J. Gen. Virol. 90: 2644-2649 [Abstract] [Full Text]  
  • Cook, S., Moureau, G., Harbach, R. E., Mukwaya, L., Goodger, K., Ssenfuka, F., Gould, E., Holmes, E. C., de Lamballerie, X. (2009). Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda. J. Gen. Virol. 90: 2669-2678 [Abstract] [Full Text]  
  • Blitvich, B. J., Juarez, L. I., Tucker, B. J., Rowley, W. A., Platt, K. B. (2009). Antibodies to West Nile Virus in Raccoons and Other Wild Peridomestic Mammals in Iowa. J Wildl Dis 45: 1163-1168 [Abstract] [Full Text]  
  • Huhtamo, E., Putkuri, N., Kurkela, S., Manni, T., Vaheri, A., Vapalahti, O., Uzcategui, N. Y. (2009). Characterization of a Novel Flavivirus from Mosquitoes in Northern Europe That Is Related to Mosquito-Borne Flaviviruses of the Tropics. J. Virol. 83: 9532-9540 [Abstract] [Full Text]  
  • Johnson, B. W., Kosoy, O., Hunsperger, E., Beltran, M., Delorey, M., Guirakhoo, F., Monath, T. (2009). Evaluation of Chimeric Japanese Encephalitis and Dengue Viruses for Use in Diagnostic Plaque Reduction Neutralization Tests. CVI 16: 1052-1059 [Abstract] [Full Text]  
  • Duffy, M. R., Chen, T.-H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C., Guillaumot, L., Griggs, A., Bel, M., Lambert, A. J., Laven, J., Kosoy, O., Panella, A., Biggerstaff, B. J., Fischer, M., Hayes, E. B. (2009). Zika Virus Outbreak on Yap Island, Federated States of Micronesia. NEJM 360: 2536-2543 [Abstract] [Full Text]  
  • Junglen, S., Kopp, A., Kurth, A., Pauli, G., Ellerbrok, H., Leendertz, F. H. (2009). A New Flavivirus and a New Vector: Characterization of a Novel Flavivirus Isolated from Uranotaenia Mosquitoes from a Tropical Rain Forest. J. Virol. 83: 4462-4468 [Abstract] [Full Text]  
  • Farfan-Ale, J. A., Lorono-Pino, M. A., Garcia-Rejon, J. E., Hovav, E., Powers, A. M., Lin, M., Dorman, K. S., Platt, K. B., Bartholomay, L. C., Soto, V., Beaty, B. J., Lanciotti, R. S., Blitvich, B. J. (2009). Detection of RNA from a Novel West Nile-like Virus and High Prevalence of an Insect-specific Flavivirus in Mosquitoes in the Yucatan Peninsula of Mexico. Am J Trop Med Hyg 80: 85-95 [Abstract] [Full Text]  
  • Kim, J.-M., Yun, S.-I., Song, B.-H., Hahn, Y.-S., Lee, C.-H., Oh, H.-W., Lee, Y.-M. (2008). A Single N-Linked Glycosylation Site in the Japanese Encephalitis Virus prM Protein Is Critical for Cell Type-Specific prM Protein Biogenesis, Virus Particle Release, and Pathogenicity in Mice. J. Virol. 82: 7846-7862 [Abstract] [Full Text]  
  • Yoshii, K., Goto, A., Kawakami, K., Kariwa, H., Takashima, I. (2008). Construction and application of chimeric virus-like particles of tick-borne encephalitis virus and mosquito-borne Japanese encephalitis virus. J. Gen. Virol. 89: 200-211 [Abstract] [Full Text]  
  • Misra, M., Schein, C. H. (2007). Flavitrack: an annotated database of flavivirus sequences. Bioinformatics 23: 2645-2647 [Abstract] [Full Text]  
  • Medeiros, D. B. A., Nunes, M. R. T., Vasconcelos, P. F. C., Chang, G.-J. J., Kuno, G. (2007). Complete genome characterization of Rocio virus (Flavivirus: Flaviviridae), a Brazilian flavivirus isolated from a fatal case of encephalitis during an epidemic in Sao Paulo state. J. Gen. Virol. 88: 2237-2246 [Abstract] [Full Text]  
  • Silva, P. A. G. C., Molenkamp, R., Dalebout, T. J., Charlier, N., Neyts, J. H., Spaan, W. J. M., Bredenbeek, P. J. (2007). Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication. J. Gen. Virol. 88: 1738-1747 [Abstract] [Full Text]  
  • Wang, H. Y., Takasaki, T., Fu, S. H., Sun, X. H., Zhang, H. L., Wang, Z. X., Hao, Z. Y., Zhang, J. K., Tang, Q., Kotaki, A., Tajima, S., Liang, X. F., Yang, W. Z., Kurane, I., Liang, G. D. (2007). Molecular epidemiological analysis of Japanese encephalitis virus in China. J. Gen. Virol. 88: 885-894 [Abstract] [Full Text]  
  • Chao, D.-Y., Davis, B. S., Chang, G.-J. J. (2007). Development of Multiplex Real-Time Reverse Transcriptase PCR Assays for Detecting Eight Medically Important Flaviviruses in Mosquitoes. J. Clin. Microbiol. 45: 584-589 [Abstract] [Full Text]  
  • Palmer, D. R., Fernandez, S., Bisbing, J., Peachman, K. K., Rao, M., Barvir, D., Gunther, V., Burgess, T., Kohno, Y., Padmanabhan, R., Sun, W. (2007). Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells. J. Gen. Virol. 88: 148-156 [Abstract] [Full Text]  
  • BENTLER, K. T., HALL, J. S., ROOT, J. J., KLENK, K., SCHMIT, B., BLACKWELL, B. F., RAMEY, P. C., CLARK, L. (2007). SEROLOGIC EVIDENCE OF WEST NILE VIRUS EXPOSURE IN NORTH AMERICAN MESOPREDATORS. Am J Trop Med Hyg 76: 173-179 [Abstract] [Full Text]  
  • KUNO, G., CHANG, G.-J. J. (2006). CHARACTERIZATION OF SEPIK AND ENTEBBE BAT VIRUSES CLOSELY RELATED TO YELLOW FEVER VIRUS. Am J Trop Med Hyg 75: 1165-1170 [Abstract] [Full Text]  
  • Grard, G., Lemasson, J.-J., Sylla, M., Dubot, A., Cook, S., Molez, J.-F., Pourrut, X., Charrel, R., Gonzalez, J.-P., Munderloh, U., Holmes, E. C., de Lamballerie, X. (2006). Ngoye virus: a novel evolutionary lineage within the genus Flavivirus.. J. Gen. Virol. 87: 3273-3277 [Abstract] [Full Text]  
  • Gritsun, T. S., Gould, E. A. (2006). Direct repeats in the 3' untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmission.. J. Gen. Virol. 87: 3297-3305 [Abstract] [Full Text]  
  • Casati, S., Gern, L., Piffaretti, J.-C. (2006). Diversity of the population of Tick-borne encephalitis virus infecting Ixodes ricinus ticks in an endemic area of central Switzerland (Canton Bern).. J. Gen. Virol. 87: 2235-2241 [Abstract] [Full Text]  
  • Chien, L.-J., Liao, T.-L., Shu, P.-Y., Huang, J.-H., Gubler, D. J., Chang, G.-J. J. (2006). Development of Real-Time Reverse Transcriptase PCR Assays To Detect and Serotype Dengue Viruses. J. Clin. Microbiol. 44: 1295-1304 [Abstract] [Full Text]  
  • May, F. J., Lobigs, M., Lee, E., Gendle, D. J., Mackenzie, J. S., Broom, A. K., Conlan, J. V., Hall, R. A. (2006). Biological, antigenic and phylogenetic characterization of the flavivirus Alfuy. J. Gen. Virol. 87: 329-337 [Abstract] [Full Text]  
  • Carrington, C. V. F., Foster, J. E., Pybus, O. G., Bennett, S. N., Holmes, E. C. (2005). Invasion and Maintenance of Dengue Virus Type 2 and Type 4 in the Americas. J. Virol. 79: 14680-14687 [Abstract] [Full Text]  
  • Hanna, S. L., Pierson, T. C., Sanchez, M. D., Ahmed, A. A., Murtadha, M. M., Doms, R. W. (2005). N-Linked Glycosylation of West Nile Virus Envelope Proteins Influences Particle Assembly and Infectivity. J. Virol. 79: 13262-13274 [Abstract] [Full Text]  
  • Kuno, G., Chang, G.-J. J. (2005). Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends. Clin. Microbiol. Rev. 18: 608-637 [Abstract] [Full Text]  
  • BRYANT, J. E., CRABTREE, M. B., NAM, V. S., YEN, N. T., DUC, H. M., MILLER, B. R. (2005). ISOLATION OF ARBOVIRUSES FROM MOSQUITOES COLLECTED IN NORTHERN VIETNAM. Am J Trop Med Hyg 73: 470-473 [Abstract] [Full Text]  
  • ROOT, J. J., HALL, J. S., MCLEAN, R. G., MARLENEE, N. L., BEATY, B. J., GANSOWSKI, J., CLARK, L. (2005). SEROLOGIC EVIDENCE OF EXPOSURE OF WILD MAMMALS TO FLAVIVIRUSES IN THE CENTRAL AND EASTERN UNITED STATES. Am J Trop Med Hyg 72: 622-630 [Abstract] [Full Text]  
  • SBRANA, E., TONRY, J. H., XIAO, S.-Y., DA ROSA, A. P. A. T., HIGGS, S., TESH, R. B. (2005). ORAL TRANSMISSION OF WEST NILE VIRUS IN A HAMSTER MODEL. Am J Trop Med Hyg 72: 325-329 [Abstract] [Full Text]  
  • Nisbet, D. J., Lee, K. J., van den Hurk, A. F., Johansen, C. A., Kuno, G., Chang, G.-J. J., Mackenzie, J. S., Ritchie, S. A., Hall, R. A. (2005). Identification of new flaviviruses in the Kokobera virus complex. J. Gen. Virol. 86: 121-124 [Abstract] [Full Text]  
  • Crill, W. D., Chang, G.-J. J. (2004). Localization and Characterization of Flavivirus Envelope Glycoprotein Cross-Reactive Epitopes. J. Virol. 78: 13975-13986 [Abstract] [Full Text]  
  • EBEL, G. D., CARRICABURU, J., YOUNG, D., BERNARD, K. A., KRAMER, L. D. (2004). GENETIC AND PHENOTYPIC VARIATION OF WEST NILE VIRUS IN NEW YORK, 2000-2003. Am J Trop Med Hyg 71: 493-500 [Abstract] [Full Text]  
  • Mutebi, J.-P., Rijnbrand, R. C. A., Wang, H., Ryman, K. D., Wang, E., Fulop, L. D., Titball, R., Barrett, A. D. T. (2004). Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3' Noncoding Region. J. Virol. 78: 9652-9665 [Abstract] [Full Text]  
  • Lee, E., Hall, R. A., Lobigs, M. (2004). Common E Protein Determinants for Attenuation of Glycosaminoglycan-Binding Variants of Japanese Encephalitis and West Nile Viruses. J. Virol. 78: 8271-8280 [Abstract] [Full Text]  
  • Keelapang, P., Sriburi, R., Supasa, S., Panyadee, N., Songjaeng, A., Jairungsri, A., Puttikhunt, C., Kasinrerk, W., Malasit, P., Sittisombut, N. (2004). Alterations of pr-M Cleavage and Virus Export in pr-M Junction Chimeric Dengue Viruses. J. Virol. 78: 2367-2381 [Abstract] [Full Text]  
  • Saha, S., Rangarajan, P. N. (2003). Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses. J. Gen. Virol. 84: 1729-1735 [Abstract] [Full Text]  
  • Holmes, E. C. (2003). Molecular Clocks and the Puzzle of RNA Virus Origins. J. Virol. 77: 3893-3897 [Full Text]  
  • Chambers, T. J., Liang, Y., Droll, D. A., Schlesinger, J. J., Davidson, A. D., Wright, P. J., Jiang, X. (2003). Yellow Fever Virus/Dengue-2 Virus and Yellow Fever Virus/Dengue-4 Virus Chimeras: Biological Characterization, Immunogenicity, and Protection against Dengue Encephalitis in the Mouse Model. J. Virol. 77: 3655-3668 [Abstract] [Full Text]  
  • Solomon, T., Ni, H., Beasley, D. W. C., Ekkelenkamp, M., Cardosa, M. J., Barrett, A. D. T. (2003). Origin and Evolution of Japanese Encephalitis Virus in Southeast Asia. J. Virol. 77: 3091-3098 [Abstract] [Full Text]  
  • Wang, W.-K., Sung, T.-L., Tsai, Y.-C., Kao, C.-L., Chang, S.-M., King, C.-C. (2002). Detection of Dengue Virus Replication in Peripheral Blood Mononuclear Cells from Dengue Virus Type 2-Infected Patients by a Reverse Transcription-Real-Time PCR Assay. J. Clin. Microbiol. 40: 4472-4478 [Abstract] [Full Text]  
  • de Lamballerie, X., Crochu, S., Billoir, F., Neyts, J., de Micco, P., Holmes, E. C., Gould, E. A. (2002). Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus. J. Gen. Virol. 83: 2443-2454 [Abstract] [Full Text]  
  • Charlier, N., Leyssen, P., Pleij, C. W. A., Lemey, P., Billoir, F., Van Laethem, K., Vandamme, A.-M., De Clercq, E., de Lamballerie, X., Neyts, J. (2002). Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector. J. Gen. Virol. 83: 1875-1885 [Abstract] [Full Text]  
  • Charlier, N., Leyssen, P., Paeshuyse, J., Drosten, C., Schmitz, H., Van Lommel, A., De Clercq, E., Neyts, J. (2002). Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis. J. Gen. Virol. 83: 1887-1896 [Abstract] [Full Text]  
  • Huelsenbeck, J. P. (2002). Testing a Covariotide Model of DNA Substitution. Mol Biol Evol 19: 698-707 [Abstract] [Full Text]  
  • Callahan, J. D., Wu, S.-J. L., Dion-Schultz, A., Mangold, B. E., Peruski, L. F., Watts, D. M., Porter, K. R., Murphy, G. R., Suharyono, W., King, C.-C., Hayes, C. G., Temenak, J. J. (2001). Development and Evaluation of Serotype- and Group-Specific Fluorogenic Reverse Transcriptase PCR (TaqMan) Assays for Dengue Virus. J. Clin. Microbiol. 39: 4119-4124 [Abstract] [Full Text]  
  • Gaunt, M. W., Sall, A. A., Lamballerie, X. d., Falconar, A. K. I., Dzhivanian, T. I., Gould, E. A. (2001). Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography. J. Gen. Virol. 82: 1867-1876 [Abstract] [Full Text]  
  • Ebel, G. D., Spielman, A., Telford, S. R. III (2001). Phylogeny of North American Powassan virus. J. Gen. Virol. 82: 1657-1665 [Abstract] [Full Text]  
  • Scaramozzino, N., Crance, J.-M., Jouan, A., DeBriel, D. A., Stoll, F., Garin, D. (2001). Comparison of Flavivirus Universal Primer Pairs and Development of a Rapid, Highly Sensitive Heminested Reverse Transcription-PCR Assay for Detection of Flaviviruses Targeted to a Conserved Region of the NS5 Gene Sequences. J. Clin. Microbiol. 39: 1922-1927 [Abstract] [Full Text]  
  • Bhardwaj, S., Holbrook, M., Shope, R. E., Barrett, A. D. T., Watowich, S. J. (2001). Biophysical Characterization and Vector-Specific Antagonist Activity of Domain III of the Tick-Borne Flavivirus Envelope Protein. J. Virol. 75: 4002-4007 [Abstract] [Full Text]  
  • Regner, M., Lobigs, M., Blanden, R. V., Milburn, P., Mullbacher, A. (2001). Antiviral Cytotoxic T Cells Cross-Reactively Recognize Disparate Peptide Determinants from Related Viruses but Ignore More Similar Self- and Foreign Determinants. J. Immunol. 166: 3820-3828 [Abstract] [Full Text]  
  • Williams, D. T., Wang, L.-F., Daniels, P. W., Mackenzie, J. S. (2000). Molecular characterization of the first Australian isolate of Japanese encephalitis virus, the FU strain. J. Gen. Virol. 81: 2471-2480 [Abstract] [Full Text]  
  • Wang, W.-K., Lee, C.-N., Kao, C.-L., Lin, Y.-L., King, C.-C. (2000). Quantitative Competitive Reverse Transcription-PCR for Quantification of Dengue Virus RNA. J. Clin. Microbiol. 38: 3306-3310 [Abstract] [Full Text]  
  • Chang, G.-J. J., Hunt, A. R., Davis, B. (2000). A Single Intramuscular Injection of Recombinant Plasmid DNA Induces Protective Immunity and Prevents Japanese Encephalitis in Mice. J. Virol. 74: 4244-4252 [Abstract] [Full Text]  
  • Yang, Z., Nielsen, R., Goldman, N., Pedersen, A.-M. K. (2000). Codon-Substitution Models for Heterogeneous Selection Pressure at Amino Acid Sites. Genetics 155: 431-449 [Abstract] [Full Text]  
  • Wang, E., Ni, H., Xu, R., Barrett, A. D. T., Watowich, S. J., Gubler, D. J., Weaver, S. C. (2000). Evolutionary Relationships of Endemic/Epidemic and Sylvatic Dengue Viruses. J. Virol. 74: 3227-3234 [Abstract] [Full Text]  
  • Billoir, F., de Chesse, R., Tolou, H., de Micco, P., Gould, E. A., de Lamballerie, X. (2000). Phylogeny of the genus Flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vector. J. Gen. Virol. 81: 781-790 [Abstract] [Full Text]  
  • Leyssen, P., De Clercq, E., Neyts, J. (2000). Perspectives for the Treatment of Infections with Flaviviridae. Clin. Microbiol. Rev. 13: 67-82 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»