This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rizzuto, C. D.
Right arrow Articles by Sodroski, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rizzuto, C. D.
Right arrow Articles by Sodroski, J. G.

 Previous Article  |  Next Article 

J. Virol., 06 1997, 4847-4851, Vol 71, No. 6
Copyright © 1997, American Society for Microbiology

Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization

CD Rizzuto and JG Sodroski
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 01225, USA.

Incorporation of the intercellular adhesion molecule ICAM-1 into human immunodeficiency virus type 1 (HIV-1) particles increased virus infectivity on peripheral blood mononuclear cells (PBMCs) by two- to sevenfold. The degree of ICAM-1-mediated enhancement was greater for viruses bearing envelope glycoproteins derived from primary HIV-1 isolates than for those bearing envelope glycoproteins from laboratory- adapted strains. Treatment of target PBMCs with an antibody against LFA- 1, a principal ICAM-1 receptor, was able to nullify the ICAM-1-mediated enhancement. The incorporation of ICAM-1 rendered HIV-1 virions less susceptible to neutralization by a monoclonal antibody directed against the viral envelope glycoproteins. Surprisingly, an antibody against ICAM-1 completely neutralized infection by ICAM-1-containing viruses, reducing the efficiency of virus entry by almost 100-fold. Thus, HIV-1 neutralization by an ICAM-1-directed antibody involves more than an inhibition of the contribution of ICAM-1 to virus entry.


This article has been cited by other articles:

  • Laguette, N., Benichou, S., Basmaciogullari, S. (2009). Human Immunodeficiency Virus Type 1 Nef Incorporation into Virions Does Not Increase Infectivity. J. Virol. 83: 1093-1104 [Abstract] [Full Text]  
  • Dai, J., Wang, P., Bai, F., Town, T., Fikrig, E. (2008). ICAM-1 Participates in the Entry of West Nile Virus into the Central Nervous System. J. Virol. 82: 4164-4168 [Abstract] [Full Text]  
  • Jolly, C., Mitar, I., Sattentau, Q. J. (2007). Adhesion Molecule Interactions Facilitate Human Immunodeficiency Virus Type 1-Induced Virological Synapse Formation between T Cells. J. Virol. 81: 13916-13921 [Abstract] [Full Text]  
  • Bobardt, M. D., Chatterji, U., Selvarajah, S., Van der Schueren, B., David, G., Kahn, B., Gallay, P. A. (2007). Cell-Free Human Immunodeficiency Virus Type 1 Transcytosis through Primary Genital Epithelial Cells. J. Virol. 81: 395-405 [Abstract] [Full Text]  
  • Chancey, C. J., Khanna, K. V., Seegers, J. F. M. L., Zhang, G. W., Hildreth, J., Langan, A., Markham, R. B. (2006). Lactobacilli-Expressed Single-Chain Variable Fragment (scFv) Specific for Intercellular Adhesion Molecule 1 (ICAM-1) Blocks Cell-Associated HIV-1 Transmission across a Cervical Epithelial Monolayer. J. Immunol. 176: 5627-5636 [Abstract] [Full Text]  
  • Tardif, M. R., Tremblay, M. J. (2005). LFA-1 Is a Key Determinant for Preferential Infection of Memory CD4+ T Cells by Human Immunodeficiency Virus Type 1. J. Virol. 79: 13714-13724 [Abstract] [Full Text]  
  • Yang, X., Kurteva, S., Ren, X., Lee, S., Sodroski, J. (2005). Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1. J. Virol. 79: 12132-12147 [Abstract] [Full Text]  
  • Li, M., Gao, F., Mascola, J. R., Stamatatos, L., Polonis, V. R., Koutsoukos, M., Voss, G., Goepfert, P., Gilbert, P., Greene, K. M., Bilska, M., Kothe, D. L., Salazar-Gonzalez, J. F., Wei, X., Decker, J. M., Hahn, B. H., Montefiori, D. C. (2005). Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies. J. Virol. 79: 10108-10125 [Abstract] [Full Text]  
  • Cantin, R., Methot, S., Tremblay, M. J. (2005). Plunder and Stowaways: Incorporation of Cellular Proteins by Enveloped Viruses. J. Virol. 79: 6577-6587 [Full Text]  
  • Roy, J., Martin, G., Giguere, J.-F., Belanger, D., Petrin, M., Tremblay, M. J. (2005). HIV Type 1 Can Act as an APC upon Acquisition from the Host Cell of Peptide-Loaded HLA-DR and CD86 Molecules. J. Immunol. 174: 4779-4788 [Abstract] [Full Text]  
  • Beausejour, Y., Tremblay, M. J. (2004). Interaction between the Cytoplasmic Domain of ICAM-1 and Pr55Gag Leads to Acquisition of Host ICAM-1 by Human Immunodeficiency Virus Type 1. J. Virol. 78: 11916-11925 [Abstract] [Full Text]  
  • Giguere, J.-F., Bounou, S., Paquette, J.-S., Madrenas, J., Tremblay, M. J. (2004). Insertion of Host-Derived Costimulatory Molecules CD80 (B7.1) and CD86 (B7.2) into Human Immunodeficiency Virus Type 1 Affects the Virus Life Cycle. J. Virol. 78: 6222-6232 [Abstract] [Full Text]  
  • Bobardt, M. D., Salmon, P., Wang, L., Esko, J. D., Gabuzda, D., Fiala, M., Trono, D., Van der Schueren, B., David, G., Gallay, P. A. (2004). Contribution of Proteoglycans to Human Immunodeficiency Virus Type 1 Brain Invasion. J. Virol. 78: 6567-6584 [Abstract] [Full Text]  
  • Tardif, M. R., Tremblay, M. J. (2003). Presence of Host ICAM-1 in Human Immunodeficiency Virus Type 1 Virions Increases Productive Infection of CD4+ T Lymphocytes by Favoring Cytosolic Delivery of Viral Material. J. Virol. 77: 12299-12309 [Abstract] [Full Text]  
  • LaBonte, J. A., Madani, N., Sodroski, J. (2003). Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression. J. Virol. 77: 6645-6659 [Abstract] [Full Text]  
  • Callahan, M. K., Popernack, P. M., Tsutsui, S., Truong, L., Schlegel, R. A., Henderson, A. J. (2003). Phosphatidylserine on HIV Envelope Is a Cofactor for Infection of Monocytic Cells. J. Immunol. 170: 4840-4845 [Abstract] [Full Text]  
  • Klasse, P. J., Sattentau, Q. J. (2002). Occupancy and mechanism in antibody-mediated neutralization of animal viruses. J. Gen. Virol. 83: 2091-2108 [Abstract] [Full Text]  
  • Giguere, J.-F., Paquette, J.-S., Bounou, S., Cantin, R., Tremblay, M. J. (2002). New Insights into the Functionality of a Virion-Anchored Host Cell Membrane Protein: CD28 Versus HIV Type 1. J. Immunol. 169: 2762-2771 [Abstract] [Full Text]  
  • Johnson, W. E., Morgan, J., Reitter, J., Puffer, B. A., Czajak, S., Doms, R. W., Desrosiers, R. C. (2002). A Replication-Competent, Neutralization-Sensitive Variant of Simian Immunodeficiency Virus Lacking 100 Amino Acids of Envelope. J. Virol. 76: 2075-2086 [Abstract] [Full Text]  
  • Bounou, S., Leclerc, J. E., Tremblay, M. J. (2002). Presence of Host ICAM-1 in Laboratory and Clinical Strains of Human Immunodeficiency Virus Type 1 Increases Virus Infectivity and CD4+-T-Cell Depletion in Human Lymphoid Tissue, a Major Site of Replication In Vivo. J. Virol. 76: 1004-1014 [Abstract] [Full Text]  
  • Johnson, D. C., Huber, M. T. (2002). Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread. J. Virol. 76: 1-8 [Full Text]  
  • Baribaud, F., Pohlmann, S., Sparwasser, T., Kimata, M. T. Y., Choi, Y.-K., Haggarty, B. S., Ahmad, N., Macfarlan, T., Edwards, T. G., Leslie, G. J., Arnason, J., Reinhart, T. A., Kimata, J. T., Littman, D. R., Hoxie, J. A., Doms, R. W. (2001). Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN. J. Virol. 75: 10281-10289 [Abstract] [Full Text]  
  • Hioe, C. E., Chien, P. C. Jr., Lu, C., Springer, T. A., Wang, X.-H., Bandres, J., Tuen, M. (2001). LFA-1 Expression on Target Cells Promotes Human Immunodeficiency Virus Type 1 Infection and Transmission. J. Virol. 75: 1077-1082 [Abstract] [Full Text]  
  • Vzorov, A. N., Compans, R. W. (2000). Effect of the Cytoplasmic Domain of the Simian Immunodeficiency Virus Envelope Protein on Incorporation of Heterologous Envelope Proteins and Sensitivity to Neutralization. J. Virol. 74: 8219-8225 [Abstract] [Full Text]  
  • Khanna, K. V., Yu, X.-F., Ford, D. H., Ratner, L., Hildreth, J. K., Markham, R. B. (2000). Differences Among HIV-1 Variants in Their Ability to Elicit Secretion of TNF-{alpha}. J. Immunol. 164: 1408-1415 [Abstract] [Full Text]  
  • Trkola, A., Gordon, C., Matthews, J., Maxwell, E., Ketas, T., Czaplewski, L., Proudfoot, A. E. I., Moore, J. P. (1999). The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity. J. Virol. 73: 6370-6379 [Abstract] [Full Text]  
  • Fujiwara, M., Tsunoda, R., Shigeta, S., Yokota, T., Baba, M. (1999). Human Follicular Dendritic Cells Remain Uninfected and Capture Human Immunodeficiency Virus Type 1 through CD54-CD11a Interaction. J. Virol. 73: 3603-3607 [Abstract] [Full Text]  
  • Lee, B., Sharron, M., Blanpain, C., Doranz, B. J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H. R., Durell, S. R., Parmentier, M., Chang, C. N., Price, K., Tsang, M., Doms, R. W. (1999). Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function. J. Biol. Chem. 274: 9617-9626 [Abstract] [Full Text]  
  • Stamatos, N. M., Mascola, J. R., Kalyanaraman, V. S., Louder, M. K., Frampton, L. M., Birx, D. L., VanCott, T. C. (1998). Neutralizing Antibodies from the Sera of Human Immunodeficiency Virus Type 1-Infected Individuals Bind to Monomeric gp120 and Oligomeric gp140. J. Virol. 72: 9656-9667 [Abstract] [Full Text]  
  • Paquette, J.-S., Fortin, J.-F., Blanchard, L., Tremblay, M. J. (1998). Level of ICAM-1 Surface Expression on Virus Producer Cells Influences both the Amount of Virion-Bound Host ICAM-1 and Human Immunodeficiency Virus Type 1 Infectivity. J. Virol. 72: 9329-9336 [Abstract] [Full Text]  
  • Cecilia, D., KewalRamani, V. N., O'Leary, J., Volsky, B., Nyambi, P., Burda, S., Xu, S., Littman, D. R., Zolla-Pazner, S. (1998). Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage. J. Virol. 72: 6988-6996 [Abstract] [Full Text]  
  • Barbeau, B., Fortin, J.-F., Genois, N., Tremblay, M. J. (1998). Modulation of Human Immunodeficiency Virus Type 1-Induced Syncytium Formation by the Conformational State of LFA-1 Determined by a New Luciferase-Based Syncytium Quantitative Assay. J. Virol. 72: 7125-7136 [Abstract] [Full Text]  
  • Wyatt, R., Sodroski, J. (1998). The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens. Science 280: 1884-1888 [Abstract] [Full Text]  
  • Mondor, I., Ugolini, S., Sattentau, Q. J. (1998). Human Immunodeficiency Virus Type 1 Attachment to HeLa CD4 Cells Is CD4 Independent and gp120 Dependent and Requires Cell Surface Heparans. J. Virol. 72: 3623-3634 [Abstract] [Full Text]  
  • Trkola, A., Ketas, T., KewalRamani, V. N., Endorf, F., Binley, J. M., Katinger, H., Robinson, J., Littman, D. R., Moore, J. P. (1998). Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage. J. Virol. 72: 1876-1885 [Abstract] [Full Text]  
  • Fortin, J.-F., Cantin, R., Tremblay, M. J. (1998). T Cells Expressing Activated LFA-1 Are More Susceptible to Infection with Human Immunodeficiency Virus Type 1 Particles Bearing Host-Encoded ICAM-1. J. Virol. 72: 2105-2112 [Abstract] [Full Text]  
  • Bounou, S., Dumais, N., Tremblay, M. J. (2001). Attachment of Human Immunodeficiency Virus-1 (HIV-1) Particles Bearing Host-encoded B7-2 Proteins Leads to Nuclear Factor-kappa B- and Nuclear Factor of Activated T Cells-dependent Activation of HIV-1 Long Terminal Repeat Transcription. J. Biol. Chem. 276: 6359-6369 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»