This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salvatori, F.
Right arrow Articles by De Rossi, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salvatori, F.
Right arrow Articles by De Rossi, A.

 Previous Article  |  Next Article 

J. Virol., Jun 1997, 4694-4706, Vol 71, No. 6
Copyright © 1997, American Society for Microbiology

Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease

F Salvatori, S Masiero, C Giaquinto, CM Wade, AJ Brown, L Chieco-Bianchi and A De Rossi
Department of Oncology and Surgical Sciences, AIDS Reference Center, University of Padova, Italy.

We addressed the relationship between the origin and evolution of human immunodeficiency virus type 1 (HIV-1) variants and disease outcome in perinatally infected infants by studying the V3 regions of viral variants in samples obtained from five transmitting mothers at delivery and obtained sequentially over the first year of life from their infected infants, two of whom (rapid progressors) rapidly progressed to having AIDS. Phylogenetic analyses disclosed that the V3 sequences from each mother-infant pair clustered together and were clearly distinct from those of the other pairs. Within each pair, the child's sequences formed a monophyletic group, indicating that a single variant initiated the infection in both rapid and slow progressors. Plasma HIV-1 RNA levels increased in all five infants during their first months of life and then declined within the first semester of life only in the three slow progressors. V3 variability increased over time in all infants, but no differences in the pattern of V3 evolution in terms of potential viral phenotype were observed. The numbers of synonymous and nonsynonymous substitutions varied during the first semester of life regardless of viral load, CD4+-cell count, and disease progression. Conversely, during the second semester of life the rate of nonsynonymous substitutions was higher than that of synonymous substitutions in the slow progressors but not in the rapid progressors, thus suggesting a stronger host selective pressure in the former. In view of the proposal that V3 genetic evolution is driven mainly by host immune constraints, these findings suggest that while the immune response to V3 might contribute to regulating viral levels after the first semester of life, it is unlikely to play a determinant role in the initial viral decline soon after birth.


This article has been cited by other articles:

  • Priceputu, E., Hanna, Z., Hu, C., Simard, M.-C., Vincent, P., Wildum, S., Schindler, M., Kirchhoff, F., Jolicoeur, P. (2007). Primary Human Immunodeficiency Virus Type 1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice. J. Virol. 81: 4677-4693 [Abstract] [Full Text]  
  • Briars, L. A., Hilao, J. J., Kraus, D. M. (2004). A Review of Pediatric Human Immunodeficiency Virus Infection. Journal of Pharmacy Practice 17: 407-431 [Abstract]  
  • Sagar, M., Lavreys, L., Baeten, J. M., Richardson, B. A., Mandaliya, K., Chohan, B. H., Kreiss, J. K., Overbaugh, J. (2003). Infection with Multiple Human Immunodeficiency Virus Type 1 Variants Is Associated with Faster Disease Progression. J. Virol. 77: 12921-12926 [Abstract] [Full Text]  
  • Wei, Q., Fultz, P. N. (2002). Differential Selection of Specific Human Immunodeficiency Virus Type 1/JC499 Variants after Mucosal and Parenteral Inoculation of Chimpanzees. J. Virol. 76: 851-864 [Abstract] [Full Text]  
  • Casado, C., Garcia, S., Rodriguez, C., del Romero, J., Bello, G., Lopez-Galindez, C. (2001). Different evolutionary patterns are found within human immunodeficiency virus type 1-infected patients. J. Gen. Virol. 82: 2495-2508 [Abstract] [Full Text]  
  • Trouplin, V., Salvatori, F., Cappello, F., Obry, V., Brelot, A., Heveker, N., Alizon, M., Scarlatti, G., Clavel, F., Mammano, F. (2001). Determination of Coreceptor Usage of Human Immunodeficiency Virus Type 1 from Patient Plasma Samples by Using a Recombinant Phenotypic Assay. J. Virol. 75: 251-259 [Abstract] [Full Text]  
  • Shankarappa, R., Margolick, J. B., Gange, S. J., Rodrigo, A. G., Upchurch, D., Farzadegan, H., Gupta, P., Rinaldo, C. R., Learn, G. H., He, X., Huang, X.-L., Mullins, J. I. (1999). Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection. J. Virol. 73: 10489-10502 [Abstract] [Full Text]  
  • Karlsson, A. C., Gaines, H., Sällberg, M., Lindbäck, S., Sönnerborg, A. (1999). Reappearance of Founder Virus Sequence in Human Immunodeficiency Virus Type 1-Infected Patients. J. Virol. 73: 6191-6196 [Abstract] [Full Text]  
  • Argentini, C, La Sorsa, V, Bruni, R, D'Ugo, E, Giuseppetti, R, Rapicetta, M (1999). Hepadnavirus evolution and molecular strategy of adaptation in a new host. J. Gen. Virol. 80: 617-626 [Abstract]  
  • Pasquier, C., Cayrou, C., Blancher, A., Tourne-Petheil, C., Berrebi, A., Tricoire, J., Puel, J., Izopet, J. (1998). Molecular Evidence for Mother-to-Child Transmission of Multiple Variants by Analysis of RNA and DNA Sequences of Human Immunodeficiency Virus Type 1. J. Virol. 72: 8493-8501 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»