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J. Virol., 05 1997, 4145-4149, Vol 71, No. 5
Copyright © 1997, American Society for Microbiology

The poly(C) region affects progression of encephalomyocarditis virus infection in Langerhans' islets but not in the myocardium

A Zimmermann, A Botta, G Arnold, HJ Eggers and B Nelsen-Salz
Institut fur Virologie der Universitat zu Koln, Cologne, Germany.

The diabetogenic variant PV2 of encephalomyocarditis virus was cloned, and three recombinants differing in their 5' poly(C) tracts were analyzed. It is shown that the poly(C) region is not essential for infectivity in mice but does influence the virus load and degree of pathological lesions within the Langerhans' islets but not in the myocardium.


This article has been cited by other articles:

  • LaRue, R., Myers, S., Brewer, L., Shaw, D. P., Brown, C., Seal, B. S., Njenga, M. K. (2003). A Wild-Type Porcine Encephalomyocarditis Virus Containing a Short Poly(C) Tract Is Pathogenic to Mice, Pigs, and Cynomolgus Macaques. J. Virol. 77: 9136-9146 [Abstract] [Full Text]  


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