This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dupraz, P. Articles by Jolicoeur, P. Search for Related Content PubMed PubMed Citation Articles by Dupraz, P. Articles by Jolicoeur, P.

 Previous Article  |  Next Article 

J. Virol., 04 1997, 2615-2620, Vol 71, No. 4
Copyright © 1997, American Society for Microbiology

The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl

P Dupraz, N Rebai, SJ Klein, N Beaulieu and P Jolicoeur
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada.

The Pr60gag protein of the murine AIDS (MAIDS) defective virus promotes the proliferation of the infected target B cells and is responsible for inducing a severe immunodeficiency disease. Using the yeast two-hybrid system, we identified the SH3 domain of c-Abl as interacting with the proline-rich p12 domain of Pr60gag. The two proteins were shown to associate in vitro and in vivo in MAIDS virus-infected B cells. Overexpression of Pr60(gag) in these cells led to a detectable increase of the levels of c-Abl protein and to its translocation at the membrane. These results suggest that this viral protein serves as a docking site for signaling molecules and that c-Abl may be involved in the proliferation of infected B cells.

This article has been cited by other articles:

• Heikkinen, L. S., Kazlauskas, A., Melen, K., Wagner, R., Ziegler, T., Julkunen, I., Saksela, K. (2008). Avian and 1918 Spanish Influenza A Virus NS1 Proteins Bind to Crk/CrkL Src Homology 3 Domains to Activate Host Cell Signaling. J. Biol. Chem. 283: 5719-5727 [Abstract] [Full Text]  
• Swanson, I., Jude, B. A., Zhang, A. R., Pucker, A., Smith, Z. E., Golovkina, T. V. (2006). Sequences within the gag Gene of Mouse Mammary Tumor Virus Needed for Mammary Gland Cell Transformation.. J. Virol. 80: 3215-3224 [Abstract] [Full Text]  
• Kim, J., Lee, J. M., Branton, P. E., Pelletier, J. (1999). Modification of EWS/WT1 functional properties by phosphorylation. Proc. Natl. Acad. Sci. USA 96: 14300-14305 [Abstract] [Full Text]  
• de Leval, L., Colombi, S., Debrus, S., Demoitie, M.-A., Greimers, R., Linsley, P., Moutschen, M., Boniver, J. (1998). CD28-B7 Costimulatory Blockade by CTLA4Ig Delays the Development of Retrovirus-Induced Murine AIDS. J. Virol. 72: 5285-5290 [Abstract] [Full Text]