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J. Virol., Mar 1997, 1906-1910, Vol 71, No. 3
Copyright © 1997, American Society for Microbiology

The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon

XY Mo, RA Tripp, MY Sangster and PC Doherty
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Sendai virus is eliminated from the respiratory tract of gamma interferon (IFN-gamma) -/- BALB/c mice with normal kinetics. The level of virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and the titers of virus-specific immunoglobulins IgG1 and IgG2b are higher in the IFN-gamma -/- mice. The emergence of this T-helper 2 response profile in both lymphoid tissue and the pneumonic lung has no obvious deleterious consequences. Virus clearance is slightly delayed following depletion of the CD4+ subset, with the effect being similar in magnitude for IFN-gamma -/- and +/+ mice. However, the generation of CTL precursors (CTLp) is diminished in the IFN-gamma -/- (but not +/+) mice in the absence of concurrent CD4+ T help. Apparently the clonal expansion of the CTLp population can be promoted either by a cytokine (perhaps IL-2) produced by the IFN-gamma -/- CD4+ T cells or by IFN- gamma made by other cell types in the +/+ mice.


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