This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mazzarelli, J. M.
Right arrow Articles by Ricciardi, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mazzarelli, J. M.
Right arrow Articles by Ricciardi, R. P.

 Previous Article  |  Next Article 

J. Virol., 10 1997, 7978-7983, Vol 71, No. 10
Copyright © 1997, American Society for Microbiology

The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135

JM Mazzarelli, G Mengus, I Davidson and RP Ricciardi
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA.

The CR3 activation domain of the human adenovirus E1A protein stimulates transcription by forming protein-protein interactions with DNA sequence-specific binding factors and components of the TFIID complex. Here, we demonstrate that CR3 can complex with the extreme C- terminal 105 amino acids of the human TATA box binding-factor- associated protein, hTAF(II)135. Furthermore, the C-terminal region of hTAF(II)135 can block transcriptional stimulation from an E1A-inducible promoter in vivo. This ability of the C terminus of hTAF(II)135 to bind CR3 and to inhibit E1A-inducible activation is highly specific. These results demonstrate for the first time that a discrete fragment of a mammalian TBP-associated factor which targets a specific activator can impair the stimulation of transcription.


This article has been cited by other articles:

  • Sengupta, T., Cohet, N., Morle, F., Bieker, J. J. (2009). Distinct modes of gene regulation by a cell-specific transcriptional activator. Proc. Natl. Acad. Sci. USA 106: 4213-4218 [Abstract] [Full Text]  
  • Pelka, P., Ablack, J. N. G., Torchia, J., Turnell, A. S., Grand, R. J. A., Mymryk, J. S. (2009). Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP. Nucleic Acids Res 37: 1095-1106 [Abstract] [Full Text]  
  • Thuault, S., Gangloff, Y.-G., Kirchner, J., Sanders, S., Werten, S., Romier, C., Weil, P. A., Davidson, I. (2002). Functional Analysis of the TFIID-specific Yeast TAF4 (yTAFII48) Reveals an Unexpected Organization of Its Histone-fold Domain. J. Biol. Chem. 277: 45510-45517 [Abstract] [Full Text]  
  • Soeth, E., Thurber, D. B., Smith, C. L. (2002). The Viral Transactivator E1A Regulates the Mouse Mammary Tumor Virus Promoter in an Isoform- and Chromatin-specific Manner. J. Biol. Chem. 277: 19847-19854 [Abstract] [Full Text]  
  • Asahara, H., Santoso, B., Guzman, E., Du, K., Cole, P. A., Davidson, I., Montminy, M. (2001). Chromatin-Dependent Cooperativity between Constitutive and Inducible Activation Domains in CREB. Mol. Cell. Biol. 21: 7892-7900 [Abstract] [Full Text]  
  • Kim, L. J., Seto, A. G., Nguyen, T. N., Goodrich, J. A. (2001). Human TAFII130 Is a Coactivator for NFATp. Mol. Cell. Biol. 21: 3503-3513 [Abstract] [Full Text]  
  • Ansieau, S., Strobl, L. J., Leutz, A. (2001). Activation of the Notch-regulated transcription factor CBF1/RBP-J{kappa} through the 13SE1A oncoprotein. Genes Dev. 15: 380-385 [Abstract] [Full Text]  
  • Russell, W. C. (2000). Update on adenovirus and its vectors. J. Gen. Virol. 81: 2573-2604 [Full Text]  
  • Mengus, G., Gangloff, Y.-G., Carre, L., Lavigne, A.-C., Davidson, I. (2000). The Human Transcription Factor IID Subunit Human TATA-binding Protein-associated Factor 28 Interacts in a Ligand-reversible Manner with the Vitamin D3 and Thyroid Hormone Receptors. J. Biol. Chem. 275: 10064-10071 [Abstract] [Full Text]  
  • Xiao, H., Hasegawa, T., Isobe, K.-i. (2000). p300 Collaborates with Sp1 and Sp3 in p21waf1/cip1 Promoter Activation Induced by Histone Deacetylase Inhibitor. J. Biol. Chem. 275: 1371-1376 [Abstract] [Full Text]  
  • Gangloff, Y.-G., Werten, S., Romier, C., Carré, L., Poch, O., Moras, D., Davidson, I. (2000). The Human TFIID Components TAFII135 and TAFII20 and the Yeast SAGA Components ADA1 and TAFII68 Heterodimerize to Form Histone-Like Pairs. Mol. Cell. Biol. 20: 340-351 [Abstract] [Full Text]  
  • Hall, K. T., Stevenson, A. J., Goodwin, D. J., Gibson, P. C., Markham, A. F., Whitehouse, A. (1999). The Activation Domain of Herpesvirus Saimiri R Protein Interacts with the TATA-Binding Protein. J. Virol. 73: 9756-9763 [Abstract] [Full Text]  
  • Rojo-Niersbach, E., Furukawa, T., Tanese, N. (1999). Genetic Dissection of hTAFII130 Defines a Hydrophobic Surface Required for Interaction with Glutamine-rich Activators. J. Biol. Chem. 274: 33778-33784 [Abstract] [Full Text]  
  • Hale, T. K., Braithwaite, A. W. (1999). The Adenovirus Oncoprotein E1a Stimulates Binding of Transcription Factor ETF to Transcriptionally Activate the p53 Gene. J. Biol. Chem. 274: 23777-23786 [Abstract] [Full Text]  
  • Lavigne, A.-C., Mengus, G., Gangloff, Y.-G., Wurtz, J.-M., Davidson, I. (1999). Human TAFII55 Interacts with the Vitamin D3 and Thyroid Hormone Receptors and with Derivatives of the Retinoid X Receptor That Have Altered Transactivation Properties. Mol. Cell. Biol. 19: 5486-5494 [Abstract] [Full Text]  
  • Lavigne, A.-C., Gangloff, Y.-G., Carre, L., Mengus, G., Birck, C., Poch, O., Romier, C., Moras, D., Davidson, I. (1999). Synergistic Transcriptional Activation by TATA-Binding Protein and hTAFII28 Requires Specific Amino Acids of the hTAFII28 Histone Fold. Mol. Cell. Biol. 19: 5050-5060 [Abstract] [Full Text]  
  • Felinski, E. A., Quinn, P. G. (1999). The CREB Constitutive Activation Domain Interacts with TATA-binding Protein-associated Factor 110 (TAF110) through Specific Hydrophobic Residues in One of the Three Subdomains Required for Both Activation and TAF110 Binding. J. Biol. Chem. 274: 11672-11678 [Abstract] [Full Text]  
  • Wang, J.-C., Strömstedt, P.-E., Sugiyama, T., Granner, D. K. (1999). The Phosphoenolpyruvate Carboxykinase Gene Glucocorticoid Response Unit: Identification of the Functional Domains of Accessory Factors HNF3{beta} (Hepatic Nuclear Factor-3{beta}) and HNF4 and the Necessity of Proper Alignment of Their Cognate Binding Sites. Mol. Endocrinol. 13: 604-618 [Abstract] [Full Text]  
  • Saluja, D., Vassallo, M. F., Tanese, N. (1998). Distinct Subdomains of Human TAFII130 Are Required for Interactions with Glutamine-Rich Transcriptional Activators. Mol. Cell. Biol. 18: 5734-5743 [Abstract] [Full Text]  
  • Ying, B., Smith, K., Spindler, K. R. (1998). Mouse Adenovirus Type 1 Early Region 1A Is Dispensable for Growth in Cultured Fibroblasts. J. Virol. 72: 6325-6331 [Abstract] [Full Text]  
  • Strom, A.-C., Ohlsson, P., Akusjarvi, G. (1998). AR1 Is an Integral Part of the Adenovirus Type 2 E1A-CR3 Transactivation Domain. J. Virol. 72: 5978-5983 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»