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J. Virol., 01 1997, 746-749, Vol 71, No. 1
Copyright © 1997, American Society for Microbiology

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Y Yoshikai, H Kidokoro, K Kimura, Y Aoki, M Makino and K Hiromatsu
Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. yyoshika@tsuru.med.nagoya-u.ac.jp

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)- reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

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