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J. Virol., 08 1996, 5716-5719, Vol 70, No. 8
Copyright © 1996, American Society for Microbiology

Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB

N Norais, JA Hall, L Gross, D Tang, S Kaur, SH Chamberlain, RL Burke and F Marcus
Chiron Corporation, Emeryville, California 94608, USA.

As part of our vaccine program, we have purified a recombinant form of human cytomegalovirus glycoprotein B that is able to induce high titers of virus-neutralizing antibodies. The isolated protein was found to be phosphorylated at a serine residue in position -7 from the C terminus of the protein. The corresponding synthetic peptide, HLKDSDEEENV, was an efficient in vitro substrate of casein kinase II.


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