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J. Virol., Aug 1996, 5711-5715, Vol 70, No. 8
Copyright © 1996, American Society for Microbiology

A simian varicella virus (SVV) homolog to varicella-zoster virus gene 21 is expressed in monkey ganglia latently infected with SVV

P Clarke, WL Matlock, T Beer and DH Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.

We have sequenced a simian varicella virus (SVV) open reading frame (ORF), 3,123 bp in length, whose product has 51% amino acid homology with the sequence encoded by the ORF of varicella-zoster virus gene 21. Several regions are highly conserved between the two ORFs, with homologies of approximately 80%. The SVV gene is transcribed in tissue culture cells productively infected with SVV and in monkey ganglia latently infected with SVV.


This article has been cited by other articles:

  • Ou, Y., Davis, K. A., Traina-Dorge, V., Gray, W. L. (2007). Simian Varicella Virus Expresses a Latency-Associated Transcript That Is Antisense to Open Reading Frame 61 (ICP0) mRNA in Neural Ganglia of Latently Infected Monkeys. J. Virol. 81: 8149-8156 [Abstract] [Full Text]  
  • Xia, D., Srinivas, S., Sato, H., Pesnicak, L., Straus, S. E., Cohen, J. I. (2002). Varicella-Zoster Virus Open Reading Frame 21, Which Is Expressed during Latency, Is Essential for Virus Replication but Dispensable for Establishment of Latency. J. Virol. 77: 1211-1218 [Abstract] [Full Text]  
  • Cohrs, R. J., Barbour, M., Gilden, D. H. (1998). Varicella-Zoster Virus Gene 21: Transcriptional Start Site and Promoter Region. J. Virol. 72: 42-47 [Abstract] [Full Text]  


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