This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lasmezas, C. I.
Right arrow Articles by Dormont, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lasmezas, C. I.
Right arrow Articles by Dormont, D.

 Previous Article  |  Next Article 

J. Virol., Feb 1996, 1292-1295, Vol 70, No. 2
Copyright © 1996, American Society for Microbiology

Immune system-dependent and -independent replication of the scrapie agent

CI Lasmezas, JY Cesbron, JP Deslys, R Demaimay, KT Adjou, R Rioux, C Lemaire, C Locht and D Dormont
Service de Neurovirologie, Commissariat a l'Energie Atomique, DSV, DRM, CRSSA, Fontenay-aux-Roses, France.

Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of the immune system for the development of scrapie after peripheral inoculation. A total of 33% of SCID mice, all but one immunologically reconstituted SCID mice (93%), and all CB17 control mice developed the disease. PrPres was detectable in the brains of all diseased animals and in the spleens of reconstituted SCID and CB17 control mice but not of the diseased non-immunologically reconstituted SCID mice. The immune system appears to be a primary target in the pathogenesis of scrapie, but direct spread to the central nervous system from the peritoneum via visceral nerve fibers can probably also occur.


This article has been cited by other articles:

  • Brown, K. L., Wathne, G. J., Sales, J., Bruce, M. E., Mabbott, N. A. (2009). The Effects of Host Age on Follicular Dendritic Cell Status Dramatically Impair Scrapie Agent Neuroinvasion in Aged Mice. J. Immunol. 183: 5199-5207 [Abstract] [Full Text]  
  • Aguzzi, A., Calella, A. M. (2009). Prions: Protein Aggregation and Infectious Diseases. Physiol. Rev. 89: 1105-1152 [Abstract] [Full Text]  
  • Bessen, R. A., Martinka, S., Kelly, J., Gonzalez, D. (2009). Role of the Lymphoreticular System in Prion Neuroinvasion from the Oral and Nasal Mucosa. J. Virol. 83: 6435-6445 [Abstract] [Full Text]  
  • Friedman-Levi, Y., Ovadia, H., Hoftberger, R., Einstein, O., Abramsky, O., Budka, H., Gabizon, R. (2007). Fatal Neurological Disease in Scrapie-Infected Mice Induced for Experimental Autoimmune Encephalomyelitis. J. Virol. 81: 9942-9949 [Abstract] [Full Text]  
  • Levavasseur, E., Metharom, P., Dorban, G., Nakano, H., Kakiuchi, T., Carnaud, C., Sarradin, P., Aucouturier, P. (2007). Experimental scrapie in 'plt' mice: an assessment of the role of dendritic-cell migration in the pathogenesis of prion diseases. J. Gen. Virol. 88: 2353-2360 [Abstract] [Full Text]  
  • Eaton, S. L., Rocchi, M., Gonzalez, L., Hamilton, S., Finlayson, J., Sales, J., Jeffrey, M., Steele, P. J., Dagleish, M. P., Rodger, S. M., Reid, H. W., Chianini, F. (2007). Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection. J. Gen. Virol. 88: 1384-1391 [Abstract] [Full Text]  
  • Jouvin-Marche, E., Attuil-Audenis, V., Aude-Garcia, C., Rachidi, W., Zabel, M., Podevin-Dimster, V., Siret, C., Huber, C., Martinic, M., Riondel, J., Villiers, C. L., Favier, A., Naquet, P., Cesbron, J.-Y., Marche, P. N. (2006). Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus. J. Immunol. 176: 3490-3497 [Abstract] [Full Text]  
  • Herzog, C., Riviere, J., Lescoutra-Etchegaray, N., Charbonnier, A., Leblanc, V., Sales, N., Deslys, J.-P., Lasmezas, C. I. (2005). PrPTSE Distribution in a Primate Model of Variant, Sporadic, and Iatrogenic Creutzfeldt-Jakob Disease. J. Virol. 79: 14339-14345 [Abstract] [Full Text]  
  • Crozet, C., Lin, Y.-L., Mettling, C., Mourton-Gilles, C., Corbeau, P., Lehmann, S., Perrier, V. (2004). Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations. J. Cell Sci. 117: 5591-5597 [Abstract] [Full Text]  
  • Solassol, J., Crozet, C., Perrier, V., Leclaire, J., Beranger, F., Caminade, A.-M., Meunier, B., Dormont, D., Majoral, J.-P., Lehmann, S. (2004). Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapie. J. Gen. Virol. 85: 1791-1799 [Abstract] [Full Text]  
  • Archer, F., Bachelin, C., Andreoletti, O., Besnard, N., Perrot, G., Langevin, C., Le Dur, A., Vilette, D., Baron-Van Evercooren, A., Vilotte, J.-L., Laude, H. (2004). Cultured Peripheral Neuroglial Cells Are Highly Permissive to Sheep Prion Infection. J. Virol. 78: 482-490 [Abstract] [Full Text]  
  • Aguzzi, A., Heppner, F. L, Heikenwalder, M., Prinz, M., Mertz, K., Seeger, H., Glatzel, M. (2003). Immune system and peripheral nerves in propagation of prions to CNS. Br Med Bull 66: 141-159 [Abstract] [Full Text]  
  • Heggebo, R., Gonzalez, L., Press, C. McL., Gunnes, G., Espenes, A., Jeffrey, M. (2003). Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep. J. Gen. Virol. 84: 1327-1338 [Abstract] [Full Text]  
  • Aucouturier, P., Carnaud, C. (2002). The immune system and prion diseases: a relationship of complicity and blindness. J. Leukoc. Biol. 72: 1075-1083 [Abstract] [Full Text]  
  • Luhr, K. M., Wallin, R. P. A., Ljunggren, H.-G., Low, P., Taraboulos, A., Kristensson, K. (2002). Processing and Degradation of Exogenous Prion Protein by CD11c+ Myeloid Dendritic Cells In Vitro. J. Virol. 76: 12259-12264 [Abstract] [Full Text]  
  • Kunzi, V., Glatzel, M., Nakano, M. Y., Greber, U. F., Van Leuven, F., Aguzzi, A. (2002). Unhampered Prion Neuroinvasion despite Impaired Fast Axonal Transport in Transgenic Mice Overexpressing Four-Repeat Tau. J. Neurosci. 22: 7471-7477 [Abstract] [Full Text]  
  • Follet, J., Lemaire-Vieille, C., Blanquet-Grossard, F., Podevin-Dimster, V., Lehmann, S., Chauvin, J.-P., Decavel, J.-P., Varea, R., Grassi, J., Fontes, M., Cesbron, J.-Y. (2002). PrP Expression and Replication by Schwann Cells: Implications in Prion Spreading. J. Virol. 76: 2434-2439 [Abstract] [Full Text]  
  • Heggebo, R., Press, C. McL., Gunnes, G., Gonzalez, L., Jeffrey, M. (2002). Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep. J. Gen. Virol. 83: 479-489 [Abstract] [Full Text]  
  • Kaeser, P. S., Klein, M. A., Schwarz, P., Aguzzi, A. (2001). Efficient Lymphoreticular Prion Propagation Requires PrPc in Stromal and Hematopoietic Cells. J. Virol. 75: 7097-7106 [Abstract] [Full Text]  
  • Glatzel, M., Aguzzi, A. (2000). PrPC expression in the peripheral nervous system is a determinant of prion neuroinvasion. J. Gen. Virol. 81: 2813-2821 [Abstract] [Full Text]  
  • Klein, M. A., Aguzzi, A. (2000). The Neuroimmune Interface in Prion Diseases. Physiology 15: 250-255 [Abstract] [Full Text]  
  • Heggebø, R., Press, C. McL., Gunnes, G., Inge Lie, K., Tranulis, M. A., Ulvund, M., Groschup, M. H., Landsverk, T. (2000). Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent. J. Gen. Virol. 81: 2327-2337 [Abstract] [Full Text]  
  • Beringue, V., Adjou, K. T., Lamoury, F., Maignien, T., Deslys, J.-P., Race, R., Dormont, D. (2000). Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent. J. Virol. 74: 5432-5440 [Abstract] [Full Text]  
  • Montrasio, F., Frigg, R., Glatzel, M., Klein, M. A., Mackay, F., Aguzzi, A., Weissmann, C. (2000). Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells. Science 288: 1257-1259 [Abstract] [Full Text]  
  • Race, R., Oldstone, M., Chesebro, B. (2000). Entry versus Blockade of Brain Infection following Oral or Intraperitoneal Scrapie Administration: Role of Prion Protein Expression in Peripheral Nerves and Spleen. J. Virol. 74: 828-833 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»