This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yasutomi, Y.
Right arrow Articles by Letvin, N. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yasutomi, Y.
Right arrow Articles by Letvin, N. L.

 Previous Article

J. Virol., Jan 1996, 678-681, Vol 70, No. 1
Copyright © 1996, American Society for Microbiology

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys

Y Yasutomi, HL Robinson, S Lu, F Mustafa, C Lekutis, J Arthos, JI Mullins, G Voss, K Manson, M Wyand and NL Letvin
Division of Viral Pathogenesis, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.


This article has been cited by other articles:

  • Chege, G. K., Shephard, E. G., Meyers, A., van Harmelen, J., Williamson, C., Lynch, A., Gray, C. M., Rybicki, E. P., Williamson, A.-L. (2008). HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine. J. Gen. Virol. 89: 2214-2227 [Abstract] [Full Text]  
  • Rosati, M., von Gegerfelt, A., Roth, P., Alicea, C., Valentin, A., Robert-Guroff, M., Venzon, D., Montefiori, D. C., Markham, P., Felber, B. K., Pavlakis, G. N. (2005). DNA Vaccines Expressing Different Forms of Simian Immunodeficiency Virus Antigens Decrease Viremia upon SIVmac251 Challenge. J. Virol. 79: 8480-8492 [Abstract] [Full Text]  
  • Someya, K., Xin, K.-Q., Matsuo, K., Okuda, K., Yamamoto, N., Honda, M. (2004). A Consecutive Priming-Boosting Vaccination of Mice with Simian Immunodeficiency Virus (SIV) gag/pol DNA and Recombinant Vaccinia Virus Strain DIs Elicits Effective Anti-SIV Immunity. J. Virol. 78: 9842-9853 [Abstract] [Full Text]  
  • Barouch, D. H., Santra, S., Tenner-Racz, K., Racz, P., Kuroda, M. J., Schmitz, J. E., Jackson, S. S., Lifton, M. A., Freed, D. C., Perry, H. C., Davies, M.-E., Shiver, J. W., Letvin, N. L. (2002). Potent CD4+ T Cell Responses Elicited by a Bicistronic HIV-1 DNA Vaccine Expressing gp120 and GM-CSF. J. Immunol. 168: 562-568 [Abstract] [Full Text]  
  • Singh, R. A. K., Wu, L., Barry, M. A. (2002). Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol. 168: 379-391 [Abstract] [Full Text]  
  • Hel, Z., Tsai, W.-P., Thornton, A., Nacsa, J., Giuliani, L., Tryniszewska, E., Poudyal, M., Venzon, D., Wang, X., Altman, J., Watkins, D. I., Lu, W., von Gegerfelt, A., Felber, B. K., Tartaglia, J., Pavlakis, G. N., Franchini, G. (2001). Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen. J. Immunol. 167: 7180-7191 [Abstract] [Full Text]  
  • Garcia-Navarro, R., Blanco-Urgoiti, B., Berraondo, P., Sanchez de la Rosa, R., Vales, A., Hervas-Stubbs, S., Lasarte, J. J., Borras, F., Ruiz, J., Prieto, J. (2001). Protection against Woodchuck Hepatitis Virus (WHV) Infection by Gene Gun Coimmunization with WHV Core and Interleukin-12. J. Virol. 75: 9068-9076 [Abstract] [Full Text]  
  • Weaver, D. J. Jr., Liu, B., Tisch, R. (2001). Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice. J. Immunol. 167: 586-592 [Abstract] [Full Text]  
  • Tisch, R., Wang, B., Weaver, D. J., Liu, B., Bui, T., Arthos, J., Serreze, D. V. (2001). Antigen-Specific Mediated Suppression of {{beta}} Cell Autoimmunity by Plasmid DNA Vaccination. J. Immunol. 166: 2122-2132 [Abstract] [Full Text]  
  • Gorelick, R. J., Benveniste, R. E., Lifson, J. D., Yovandich, J. L., Morton, W. R., Kuller, L., Flynn, B. M., Fisher, B. A., Rossio, J. L., Piatak, M. Jr., Bess, J. W. Jr., Henderson, L. E., Arthur, L. O. (2000). Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost. J. Virol. 74: 11935-11949 [Abstract] [Full Text]  
  • Egan, M. A., Charini, W. A., Kuroda, M. J., Schmitz, J. E., Racz, P., Tenner-Racz, K., Manson, K., Wyand, M., Lifton, M. A., Nickerson, C. E., Fu, T., Shiver, J. W., Letvin, N. L. (2000). Simian Immunodeficiency Virus (SIV) gag DNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection. J. Virol. 74: 7485-7495 [Abstract] [Full Text]  
  • Raviprakash, K., Porter, K. R., Kochel, T. J., Ewing, D., Simmons, M., Phillips, I., Murphy, G. S., Weiss, W. R., Hayes, C. G. (2000). Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques. J. Gen. Virol. 81: 1659-1667 [Abstract] [Full Text]  
  • Allen, T. M., Vogel, T. U., Fuller, D. H., Mothe, B. R., Steffen, S., Boyson, J. E., Shipley, T., Fuller, J., Hanke, T., Sette, A., Altman, J. D., Moss, B., McMichael, A. J., Watkins, D. I. (2000). Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen. J. Immunol. 164: 4968-4978 [Abstract] [Full Text]  
  • Kerkhofs, P., Gatot, J.-S., Knapen, K., Mammerickx, M., Burny, A., Portetelle, D., Willems, L., Kettmann, R. (2000). Long-term protection against bovine leukaemia virus replication in cattle and sheep. J. Gen. Virol. 81: 957-963 [Abstract] [Full Text]  
  • Li, Z., Howard, A., Kelley, C., Delogu, G., Collins, F., Morris, S. (1999). Immunogenicity of DNA Vaccines Expressing Tuberculosis Proteins Fused to Tissue Plasminogen Activator Signal Sequences. Infect. Immun. 67: 4780-4786 [Abstract] [Full Text]  
  • Calarota, S. A., Leandersson, A.-C., Bratt, G., Hinkula, J., Klinman, D. M., Weinhold, K. J., Sandstrom, E., Wahren, B. (1999). Immune Responses in Asymptomatic HIV-1-Infected Patients After HIV-DNA Immunization Followed by Highly Active Antiretroviral Treatment. J. Immunol. 163: 2330-2338 [Abstract] [Full Text]  
  • Chen, Y, Usherwood, E., Surman, S., Hogg, T., Woodland, D. (1999). Long-term CD8+ T cell memory to Sendai virus elicited by DNA vaccination. J. Gen. Virol. 80: 1393-1399 [Abstract]  
  • Verschoor, E. J., Mooij, P., Oostermeijer, H., van der Kolk, M., ten Haaft, P., Verstrepen, B., Sun, Y., Morein, B., Åkerblom, L., Fuller, D. H., Barnett, S. W., Heeney, J. L. (1999). Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance. J. Virol. 73: 3292-3300 [Abstract] [Full Text]  
  • Cohen, Adam. D., Boyer, J. D., Weiner, D. B. (1998). Modulating the immune response to genetic immunization. FASEB J. 12: 1611-1626 [Abstract] [Full Text]  
  • Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K. M., Charoenvit, Y., Jones, T. R., Hobart, P., Margalith, M., Ng, J., Weiss, W. R., Sedegah, M., de Taisne, C., A. Norman, J., Hoffman, S. L. (1998). Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine. Science 282: 476-480 [Abstract] [Full Text]  
  • Wang, R., Doolan, D. L., Charoenvit, Y., Hedstrom, R. C., Gardner, M. J., Hobart, P., Tine, J., Sedegah, M., Fallarme, V., Sacci, J. B. Jr., Kaur, M., Klinman, D. M., Hoffman, S. L., Weiss, W. R. (1998). Simultaneous Induction of Multiple Antigen-Specific Cytotoxic T Lymphocytes in Nonhuman Primates by Immunization with a Mixture of Four Plasmodium falciparum DNA Plasmids. Infect. Immun. 66: 4193-4202 [Abstract] [Full Text]  
  • Hosie, M. J., Flynn, J. N., Rigby, M. A., Cannon, C., Dunsford, T., Mackay, N. A., Argyle, D., Willett, B. J., Miyazawa, T., Onions, D. E., Jarrett, O., Neil, J. C. (1998). DNA Vaccination Affords Significant Protection against Feline Immunodeficiency Virus Infection without Inducing Detectable Antiviral Antibodies. J. Virol. 72: 7310-7319 [Abstract] [Full Text]  
  • Barouch, D. H., Santra, S., Steenbeke, T. D., Zheng, X. X., Perry, H. C., Davies, M.-E., Freed, D. C., Craiu, A., Strom, T. B., Shiver, J. W., Letvin, N. L. (1998). Augmentation and Suppression of Immune Responses to an HIV-1 DNA Vaccine by Plasmid Cytokine/Ig Administration. J. Immunol. 161: 1875-1882 [Abstract] [Full Text]  
  • Chen, S. C., Jones, D. H., Fynan, E. F., Farrar, G. H., Clegg, J. C. S., Greenberg, H. B., Herrmann, J. E. (1998). Protective Immunity Induced by Oral Immunization with a Rotavirus DNA Vaccine Encapsulated in Microparticles. J. Virol. 72: 5757-5761 [Abstract] [Full Text]  
  • Andre, S., Seed, B., Eberle, J., Schraut, W., Bultmann, A., Haas, J. (1998). Increased Immune Response Elicited by DNA Vaccination with a Synthetic gp120 Sequence with Optimized Codon Usage. J. Virol. 72: 1497-1503 [Abstract] [Full Text]  
  • Chow, Y.-H., Chiang, B.-L., Lee, Y.-L., Chi, W.-K., Lin, W.-C., Chen, Y.-T., Tao, M.-H. (1998). Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes. J. Immunol. 160: 1320-1329 [Abstract] [Full Text]  
  • Tobery, T. W., Siliciano, R. F. (1997). Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo After Immunization. JEM 185: 909-920 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»