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J Virol. 1992 February; 66(2): 1202-1206

Finite life span of hybrids formed by fusion of different simian virus 40-immortalized human cell lines.

N J Whitaker, E L Kidston and R R Reddel

Children's Medical Research Foundation, Camperdown, New South Wales, Australia.

ABSTRACT

Simian virus 40 (SV40) genes are able to induce immortalization of normal human cells after a culture crisis during which unknown cellular genetic changes presumably occur. To determine whether these genetic changes are always identical, we performed somatic cell hybridization analysis of an SV40-immortalized human bronchial epithelial cell line, BET-1A. Fusion of BET-1A with an SV40-immortalized fibroblast cell line resulted in hybrids that senesced, indicating that these cell lines are in different complementation groups for immortalization.

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J Virol. 1992 February; 66(2): 1202-1206

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