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J Virol. 1989 May; 63(5): 2352-2356

Alterations in the structure of new and old forms of simian virus 40 large T antigen (T) defined by age-dependent epitope changes: new T is the same as ATPase-active T.

L C Tack, J H Wright and E G Gurney

Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92138-9216.

ABSTRACT

The reactivity of simian virus 40 large T antigen labeled under pulse-chase conditions towards 22 antibodies was measured. Changes in epitope reactivity occurred in several domains of T as it matured, defining major structural alterations that distinguished mature from new molecules. New T reacted best with the same antibodies that bind and inhibit ATPase-active T. These antibodies thus can distinguish new T as a distinct structural and functional form.

J Virol. 1989 May; 63(5): 2352-2356






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