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J Virol. 1979 January; 29(1): 405-408

Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis.

V Zaslavsky

ABSTRACT

Accumulation of thymidine kinase activity in vaccinia virus-infected cells was severely inhibited by zinc ions if the drug was added within 1 h postinfection. If added later, zinc ions had no effect on the enzyme synthesis. A fraction of RNA which is normally synthesized in infected cells, was missing from a proper part of the gradient if the cells were treated with zinc ions within 1 h postinfection (as has been shown by cosedimentation of pulse-labeled RNAs in isokinetic gradients). It is suggested that a transcriptional (or posttranscriptional) step is involved in zinc-caused inhibition of vaccinia virus growth.

J Virol. 1979 January; 29(1): 405-408






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J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1979 by the American Society for Microbiology. All rights reserved.