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J Virol. 1976 February; 17(2): 513-524

Persistent reovirus infection of CHO cells resulting in virus resistance.

R Taber, V Alexander and W Whitford

ABSTRACT

We obtained a persistently infected line of Chinese hamster ovary cells by selection for resistance to reovirus infection. The cells were persistently infected by a population of viruses that were (i) cytopathic for parental chinese hamster ovary cells and (ii) similar to wild-type reovirus in molecular characteristics. The growth rate, plating efficiency, and morphology of the cells were altered. A large majority of the cells in the population were infected. There was no detectable interferon present in the medium. The cells were relatively resistant to a wide range of viruses.

J Virol. 1976 February; 17(2): 513-524






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