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J Virol. 1974 August; 14(2): 300-306
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Rhabdovirus Replication in Enucleated Host Cells

¹ The Wistar Institute of Anatomy and Biology, World Health Organization International Reference Center for Rabies, Philadelphia, Pennsylvania 19104

ABSTRACT

Infection of enucleated TC-7 monkey cells with rabies virus resulted in the synthesis of virus-directed RNA and the production of rabies antigens but not of infectious virus. The yield of infectious vesicular stomatitis virus from enucleated TC-7 cells, on the other hand, was almost as high as that from intact cells. Inhibition of the mitochondrial functions of enucleated cells by treatment with ethidium bromide did not influence the development of rabies antigens or the production of infectious vesicular stomatitis virus.