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J Virol. 1974 April; 13(4): 775-779
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Selective Inhibition of Newcastle Disease Virus-Induced Glycoprotein Synthesis by D-Glucosamine Hydrochloride

^a Department of Bacteriology and the Molecular Biology Institute, University of California, Los Angeles, California 90024

ABSTRACT

D-Glucosamine selectively affected the synthesis of virus-induced glycoproteins in Newcastle disease virus-infected chick fibroblasts, but had no effect upon post-translational cleavage of the glycoprotein precursor for one of the two major glycoproteins of the mature virion. In response to glucosamine, at least one of the two virus-induced glycoproteins is formed in reduced quantity and the second is either not formed or has an electrophoretic mobility identical to that of another virus-induced protein.

¹ Present address: Department of Genetics, University of Newcastle Upon Tyne, Newcastle Upon Tyne, England.