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J Virol. 1967 December; 1(6): 1150-1157
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Transient Inhibition of Avian Myeloblastosis Virus Reproduction by Amethopterin and Fluorodeoxyuridine

^a Department of Biology, City of Hope Medical Center, Duarte, California 91010

ABSTRACT

Avian myeloblastosis virus cannot initiate its reproduction in the presence of amethopterin or fluorodeoxyuridine. This inhibition is reversed by thymidine. Addition of either inhibitor after virus production has started does not inhibit further virus synthesis. In presence of either inhibitor, deoxyribonucleic acid synthesis is inhibited by over 90%, but ribonucleic acid synthesis is not affected. Cells resume their normal growth rate 24 hr after removal of either inhibitor.

¹ Present address: School of Medicine, The State University of New York, Stony Brook, N.Y.

² Recipient of Postdoctoral Fellowship 5-F2 CA-21,127 from the National Cancer Institute. Present address: Department of Biology, California State College, Long Beach, Calif.

³ Present address: School of Medicine, University of California, Los Angeles, Calif. 90024.