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J Virol. 1967 August; 1(4): 678-683
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Nature of Hamster Complement-fixing Antibody to Adenovirus 12 Tumor Antigen

¹ Department of Microbiology, University of Miami School of Medicine and Variety Children's Research Foundation, Miami, Florida 33155

ABSTRACT

The presence of complement-fixing (CF) antibody reactive with T antigen and with viral C antigen in hamsters bearing adenovirus 12-induced tumors has been confirmed. Antibody activity in serum obtained at a time when the host was bearing large tumors was found to be associated exclusively with 7S immunoglobulins. Two populations of 7S immunoglobulins showing CF reactivity were distinguished by electrical charge, as determined by diethylaminoethyl cellulose chromatography and immunoelectrophoresis. No antibodies of the 19S IgM type were detected in the serum of hamsters bearing large tumors.