Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Impact of increasing amounts of p56^lck on Nef-induced CD4 down-regulation.)
  TIF file, 150K.
• Supplemental file 2 - Fig. S2 (Effect of a 6-h treatment with NH₄Cl and MG132 on lysosome acidification and proteasome activity.)
  TIF file, 132K.
• Supplemental file 3 - Fig. S3 (Contribution of HIV-1 Nef motifs to CD4 downregulation.)
  TIF file, 155K.
• Supplemental file 4 - Fig. S4 (HIV-1 and SIVmac239 Nef do not cause an increase of CD4 internalization rate in myeloid cells.)
  TIF file, 126K.
• Supplemental file 5 - Fig. S5 (Similar expression levels of Nef cause an increase of CD4 internalization in HPB-ALL but not in THP-1 nor in HeLa-CD4.)
  TIF file, 224K.
• Supplemental file 6 - Supplemental figure legends.
  MS Word document, 27K.