Files in this Data Supplement:

• Supplemental file 1 - Legends to supplemental figures
  Zipped Word file, 8K.
• Supplemental file 2 - Fig. S1 (Lysosomal accumulation of CD4 downregulated by Nef in the presence of monensin.)
  Zipped TIFF file, 964K
• Supplemental file 3 - Fig. S2 (Nef ubiquitination is not required for CD4 redistribution to endosomes.)
  Zipped TIFF file, 2.7MB.
• Supplemental file 4 - Fig. S3 (CD4 downregulation is independent of Nef ubiquitination in A3.01 T cells.)
  Zipped TIFF file, 210K.
• Supplemental file 5 - Fig. S4 (Visualization of CD4 and Nef in endosomal structures.)
  Zipped TIFF file, 756K.