Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Urea denaturation assay.) Fig. S2 (Western blot showing representative brain homogenates from inoculated animals.) Fig. S3 (Representative histological fields of cerebral cortex.) Fig. S4 (Representative histological fields of cerebral cortex and cerebellum.) Fig. S5 (Regional neuropathology of mice injected with samples produced by sPMCA using normal mouse brain homogenate as substrate.)
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