Files in this Data Supplement:

• Supplemental file 1 - Fig. S1 (Fold increase in transcripts for indicated host and viral genes from a pooled sample is representative of data from individual mice.)
  Zipped TIF file, 576K.
• Supplemental file 2 - Fig. S2 (Didactic figure to show experimental design.)
  Zipped TIF file, 412K.
• Supplemental file 3 - Fig. S3 (Heat maps show early, intermediate, late, early/intermediate, and intermediate/late differential cellular gene expression in lung samples of young SARS-CoV-infected mice.)
  Zipped TIF file, 2MB.
• Supplemental file 4 - Fig. S3, continued
  Zipped TIF file, 1.3MB.
• Supplemental file 5 - Fig. S4 (Heat maps show early, intermediate, late, early/intermediate, and intermediate/late differential cellular gene expression in lung samples of aged SARS-CoV-infected mice.)
  Zipped TIF File, 1.6MB.
• Supplemental file 6 - Fig. S4, continued
  Zipped TIF file, 1.8MB.
• Supplemental file 7 - Fig. S5 (Aged mice showed differences compared to young mice even before viral infection.)
  Zipped TIF file, 3MB.
• Supplemental file 8 - Fig. S6 (Network interactions show a number of genes with lower levels of gene expression in mock-infected aged mice compared with mock-infected young mice.)
  Zipped TIF file, 1.5MB.
• Supplemental file 9 - Fig. S7 (Pathway analyses of Jak/Stat/Ifn in (A) aged and (B) young SARS-CoV-infected mice.)
  Zipped TIF file, 1.3MB.
• Supplemental file 10 - Fig. S8 (Global gene expression shows that aged mice mount an inappropriate response to virus.)
  Zipped TIF file, 508K.
• Supplemental file 11 - Legends to supplemental figures
  MS Word document, 32K.