The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 4E10 Monoclonal Antibody Is Better Adapted to Membrane-Bound Epitope Recognition and Blocking than 2F5
J. Virol. Huarte et al.
82: 8986
Supplemental material
Files in this Data Supplement:
- Supplemental file 1 -
Fig. S1 (Amide I band contours (solid lines) and component bands (dotted lines) of the infrared spectra of AIS, PreTM, and AISpreTM in the presence of DPC micelles.)
Fig. S2 (Differential insertion and partitioning into membranes of AIS and AISpreTM.)
Fig. S3 (Model based on “partitioning-coupled folding” to explain the lower in-membrane recognition by the 2F5 than by the 4E10 MAb.)
Table S1 (Band position, assignment, and % area of the components obtained from the curve-fitting of IR spectra displayed in Fig. S1.)
PDF file, 1.2MB.
