Files in this Data Supplement:

• Supplemental file 8 - HERV-K tree without CTS and cPPT regions.)
  PDF file, 7K.
• Supplemental file 1 - Fig. S1A
  Zipped MS Word document, 25K.
• Supplemental file 2 - Fig. S1B (Fasta alignments of HIV-1 proviral sequences hypermutated in vitro by (A) hA3G and (B) hA3F.)
  Zipped MS Word document, 23K.
• Supplemental file 3 - Fig. S2 (Mutation frequencies at each G-containing tetranucleotide context for each individual sequence hypermutated in vitro by (A) hA3G and (B) hA3F and for the pooled datasets.)
  Zipped MS Excel file, 82K.
• Supplemental file 4 - Fig. S3 (Fasta alignment of HERV-K(HML2) sequences.)
  Zipped MS Word document, 67K.
• Supplemental file 5 - Fig. S4 (Profiles of hypermutation across near full-length proviral genomes hypermutated in vitro by hA3G and hA3F.)
  Zipped TIF file, 268K.
• Supplemental file 6 - Fig. S5, part 1.
  Zipped TIF file, 490K.
• Supplemental file 7 - Fig. S5, part 2 (Remaining profiles of hypermutation in proviruses derived from natural infections.)
  Zipped TIF file, 259K.
• Supplemental file 9 - Table S1 (PCR and sequencing primers used for sequencing near full-length HIV-1 proviruses.)
  Table S2 (Catalogue of hypermutated sequences analyzed from the Los Alamos HIV sequence database and sequences used for generating reference sequence estimates.)
  Table S3 (Chromosomal locations of HERV-K(HML2) elements in the human genome.)
  Zipped MS Word document, 21K.