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Journal of Virology, December 2000, p. 12003a-12003a, Vol. 74, No. 24
Replication of Herpes Simplex Virus Type 1 within
Trigeminal Ganglia Is Required for High Frequency but Not
High Viral Genome Copy Number Latency
Department of Molecular Genetics, Microbiology, and Biochemistry,
University of Cincinnati Medical Center, Cincinnati, Ohio
45267-0524, and Division of Infectious Diseases, Children's
Hospital Medical Center, Cincinnati, Ohio 45229-3039
Volume 74, no. 2, p. 964-974, 2000. Page 971, column 2, 2nd full
paragraph, lines 8-11: The sentence beginning "In mouse TG," should read "In mouse TG, Coen et al. (4) observed reduced numbers of
LAT+ neurons in mice latently infected with a
TK Page 973, column 1, last paragraph of the text. Line 8: "(1, 44)"
should read "(1, 14a, 44)."
The following should be added to the References:
14a. Garber, D. A., P. A. Schaffer, and D. M. Knipe. 1997. A LAT-associated function reduces
productive-cycle gene expression during acute infection of murine
sensory neurons with herpes simplex virus type 1. J. Virol.
71:5885-5893.
21a. Jacobson, J. G., K. L. Ruffner, M. Kosz-Vnenchak, C. B. Hwang, K. K. Wobbe, D. M. Knipe, and
D. M. Coen. 1993. Herpes simplex virus thymidine kinase and
specific stages of latency in murine trigeminal ganglia. J. Virol.
67:6903-6908.
0022-538X/00
Copyright © 2000, American Society for Microbiology. All rights reserved.
AUTHOR'S CORRECTION
mutant and Jacobson et al. (21a) showed that this
reduction was due to a TK mutation that does not affect the UL24 gene
or its expression. In addition, quantitative PCR analysis of the viral genome has revealed a significant decrease in the amount of latent DNA
present in the TG of mice latently infected with TK-null mutants (22, 25, 26)."
Journal of Virology, December 2000, p. 12003a-12003a, Vol. 74, No. 24
0022-538X/00
Copyright © 2000, American Society for Microbiology. All rights reserved.
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