JVI Accepts, published online ahead of print on 23 January 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pandrea, I. Articles by Apetrei, C. Search for Related Content PubMed PubMed Citation Articles by Pandrea, I. Articles by Apetrei, C.

 Previous Article  |  Next Article 

J. Virol. doi:10.1128/JVI.02402-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

SIVagm Dynamics in African Green Monkeys

Ivona Pandrea^*, Ruy M. Ribeiro, Rajeev Gautam, Thaidra Gaufin, Melissa Pattison, Mary Barnes, Christopher Monjure, Crystal Stoulig, Jason Dufour, Wayne Cyprian, Guido Silvestri, Michael D. Miller, Alan S. Perelson, and Cristian Apetrei

Divisions of Comparative Pathology, Microbiology, and Veterinary Medicine Tulane National Primate Research Center, Covington Louisiana 70433, USA; Department of Pathology, School of Medicine, Tulane University, New Orleans, Louisiana 70112, USA; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA; Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA; Gilead Sciences, Inc, Foster City, California 94404, USA; Department of Tropical Medicine, School of Public Health, Tulane University, New Orleans, Louisiana 70112, USA

^* To whom correspondence should be addressed. Email: ipandrea{at}tulane.edu.

The mechanisms underlying the lack of disease progression in natural SIV hosts are still poorly understood. To test the hypothesis that SIV-infected AGMs avoid AIDS due to virus replication occurring in long-lived infected cells, we infected six animals with SIVagm and treated them with potent antiretroviral therapy [ART: (PMPA, tenofovir) and (FTC, emtricitabine)]. All AGMs showed a rapid decay of plasma viremia that became undetectable 36 hours after ART initiation. Significant decrease of viral load was observed in PBMCs and intestine. Mathematical modeling of viremia decay post-ART indicates a half-life of productively infected cells ranging from 4 to 9.5 h, i.e., faster than previously reported for HIV and SIV. ART induced a slight but significant increase in peripheral CD4⁺ T-cell counts but no significant changes in CD4⁺ T-cell levels in LNs and intestine. Similarly, ART did not significantly change the levels of cell proliferation, activation and apoptosis, already low in chronically SIVagm-infected AGMs. Collectively, these results indicate that, in SIVagm-infected AGMs, the bulk of virus replication is sustained by short-lived cells; therefore, differences in disease outcome between SIVmac infection of macaques and SIVagm infection of AGMs are unlikely due to intrinsic differences of the in vivo cytopathicity between the two viruses.

This article has been cited by other articles:

• Gaufin, T., Pattison, M., Gautam, R., Stoulig, C., Dufour, J., MacFarland, J., Mandell, D., Tatum, C., Marx, M. H., Ribeiro, R. M., Montefiori, D., Apetrei, C., Pandrea, I. (2009). Effect of B-Cell Depletion on Viral Replication and Clinical Outcome of Simian Immunodeficiency Virus Infection in a Natural Host. J. Virol. 83: 10347-10357 [Abstract] [Full Text]  
• Gautam, R., Gaufin, T., Butler, I., Gautam, A., Barnes, M., Mandell, D., Pattison, M., Tatum, C., Macfarland, J., Monjure, C., Marx, P. A., Pandrea, I., Apetrei, C. (2009). Simian Immunodeficiency Virus SIVrcm, a Unique CCR2-Tropic Virus, Selectively Depletes Memory CD4+ T Cells in Pigtailed Macaques through Expanded Coreceptor Usage In Vivo. J. Virol. 83: 7894-7908 [Abstract] [Full Text]  
• Gaufin, T., Gautam, R., Kasheta, M., Ribeiro, R., Ribka, E., Barnes, M., Pattison, M., Tatum, C., MacFarland, J., Montefiori, D., Kaur, A., Pandrea, I., Apetrei, C. (2009). Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. Blood 113: 4250-4261 [Abstract] [Full Text]  
• Souquiere, S., Onanga, R., Makuwa, M., Pandrea, I., Ngari, P., Rouquet, P., Bourry, O., Kazanji, M., Apetrei, C., Simon, F., Roques, P. (2009). Simian immunodeficiency virus types 1 and 2 (SIV mnd 1 and 2) have different pathogenic potentials in rhesus macaques upon experimental cross-species transmission. J. Gen. Virol. 90: 488-499 [Abstract] [Full Text]  
• Pandrea, I., Gaufin, T., Brenchley, J. M., Gautam, R., Monjure, C., Gautam, A., Coleman, C., Lackner, A. A., Ribeiro, R. M., Douek, D. C., Apetrei, C. (2008). Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion. J. Immunol. 181: 6687-6691 [Abstract] [Full Text]  
• Gordon, S. N., Dunham, R. M., Engram, J. C., Estes, J., Wang, Z., Klatt, N. R., Paiardini, M., Pandrea, I. V., Apetrei, C., Sodora, D. L., Lee, H. Y., Haase, A. T., Miller, M. D., Kaur, A., Staprans, S. I., Perelson, A. S., Feinberg, M. B., Silvestri, G. (2008). Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis. J. Virol. 82: 3725-3735 [Abstract] [Full Text]