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J Virol. 1972 June; 9(6): 946-955
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Genome Homology of Vesicular Stomatitis Virus and Defective T Particles and Evidence for the Sequential Transcription of the Virion Ribonucleic Acid

Institute of Microbiology, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey 08903

ABSTRACT

The small defective T particle of vesicular stomatitis virus (VSV-111) has no detectable enzyme activity when assayed at 31 C, although qualitatively it possesses all the virion proteins found in complete VSV-1 virions. With VSV-1 transcription product ribonucleic acid (RNA), it is shown that the VSV-111 RNA is identical to part of the VSV-1 genome. Evidence is also presented to support the idea that in vitro VSV-1 transcription is sequential.