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J Virol. 1972 June; 9(6): 917-922
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Metabolism of T4 Bacteriophage Ghost-Infected Cells II. Do Ghosts Cause a Generalized Permeability Change?

Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22903

ABSTRACT

Ghosts appear to alter the barrier function of the cell membrane, allowing the release of phosphorylated sugars which normally cannot pass through the cell membrane, whereas phage do not. No increased influx of normally impermeable compounds is observed in the presence of ghosts, indicating that the loss of membrane function after ghost infection cannot be attributed to a generalized breakdown of the permeability barrier.