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J Virol. 1972 May; 9(5): 804-812
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Regulation of Bacteriophage T5 Development by ColI Factors

¹ Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

The I-type colicinogenic factor ColIb transforms Escherichia coli from a permissive to a nonpermissive host for bacteriophage T5 reproduction by preventing complete expression of the phage genome. T5-infected ColIb⁺ cells synthesize only class I (early) phage protein and ribonucleic acid (RNA). Neither phage-specific class II proteins [associated with viral deoxyribonucleic acid (DNA) replication] nor class III proteins (phage structural components) are formed due to the failure of the infected ColIb⁺ cells to synthesize class II or class III phage-specific messenger RNA. Comparable studies with T5-infected cells colicinogenic for the related ColIa factor revealed no decrease in the yield of progeny phage although the presence of the ColIa factor leads to a significant reduction in the amount of phage-directed class III protein synthesis.