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J Virol. 1972 May; 9(5): 752-757
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Inhibitory Effect of Bacteriophage P22 Infection on Host Cell Deoxyribonuclease Activity

^a Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104

ABSTRACT

Infection of Salmonella typhimurium with phage P22 causes a decrease in the activity of host deoxyribonuclease which degrades single-stranded deoxyribonucleic acid (DNA). This decrease is reversed when the infecting phage is P22c⁺; it is not reversed if the infecting phage kills the cell. The decrease does not occur in infections with P22ts25.1 (which only adsorbs and injects DNA) or in infections of a lysogen by a nonvirulent phage. It does occur, however, after infections with other phages which are blocked in phage DNA synthesis. Inhibiting protein synthesis with chloramphenicol does not in itself cause the decrease in uninfected cells, but it does prevent infected cells from showing this effect.

¹ Present address: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Ga. 30902.